NDUFB3 Antibody (31-B): sc-100564

NDUFB3 Antibody (31-B) is a mouse monoclonal IgG2a antibody that detects NDUFB3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). NDUFB3, also known as NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3, is a crucial 98 amino acid hydrophobic protein that plays an essential role as an accessory subunit of Complex I in the mitochondrial inner membrane. NDUFB3 is vital for the proper functioning of the electron transport chain, facilitating the transfer of electrons from NADH to ubiquinone, ultimately contributing to ATP synthesis by creating an electrochemical proton gradient. The structural integrity of NDUFB3 is important, as NDUFB3 is part of a complex assembly of at least 45 different subunits, and any alterations in its structure can lead to impaired mitochondrial function and energy production, which are critical for cellular metabolism and overall cellular health. Anti-NDUFB3 antibody (31-B) is an invaluable tool for researchers studying mitochondrial function and related metabolic disorders, providing insights into the intricate mechanisms of energy production at the cellular level.

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NDUFB3 Antibody (31-B) References:

1. Assignment of human NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 (NDUFB3) and of its four pseudogenes to human chromosomes 2q31.3, 1p13.3-->p13.1, 9q32-->q34.1, 14q22.3-->q23.1 and 14q32.2 by radiation hybrid mapping.  |  Jensen, LL., et al. 2001. Cytogenet Cell Genet. 93: 147-50. PMID: 11474204
2. A recurrent mitochondrial p.Trp22Arg NDUFB3 variant causes a distinctive facial appearance, short stature and a mild biochemical and clinical phenotype.  |  Alston, CL., et al. 2016. J Med Genet. 53: 634-41. PMID: 27091925
3. Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma.  |  Chung, IC., et al. 2020. Mol Cell Proteomics. 19: 142-154. PMID: 31723016
4. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.  |  Davydova, E., et al. 2021. Nat Commun. 12: 891. PMID: 33563959
5. Clinical Relevance and Tumor Growth Suppression of Mitochondrial ROS Regulators along NADH:Ubiquinone Oxidoreductase Subunit B3 in Thyroid Cancer.  |  Zhu, J., et al. 2022. Oxid Med Cell Longev. 2022: 8038857. PMID: 35087620
6. Identification and experimental validation of mitochondria-related genes biomarkers associated with immune infiltration for sepsis.  |  Shu, Q., et al. 2023. Front Immunol. 14: 1184126. PMID: 37228596
7. The role of lactylation in plasma cells and its impact on rheumatoid arthritis pathogenesis: insights from single-cell RNA sequencing and machine learning.  |  Fu, W., et al. 2024. Front Immunol. 15: 1453587. PMID: 39421742
8. Comprehensive Analysis of NADH:Ubiquinone Oxidoreductase Subunit B3 in Gynecological Tumors and Identification of Its Natural Inhibitor Wedelolactone.  |  Li, H., et al. 2024. Chem Biol Drug Des. 104: e70006. PMID: 39469770
9. Role of COX6C and NDUFB3 in septic shock and stroke.  |  Tian, W., et al. 2024. Open Med (Wars). 19: 20241050. PMID: 39655053
10. New Posttranslational Modification Lactylation Brings New Inspiration for the Treatment of Rheumatoid Arthritis.  |  Yang, Y., et al. 2024. J Inflamm Res. 17: 11845-11860. PMID: 39758940

The preferred NDUFB3 antibody is NDUFB3 Antibody (F-12): sc-393351.