MULK Antibody (C-7): sc-398943
- MULK Antibody (C-7) is a mouse monoclonal mouse IgG1 κ κ provided at 200 µg/ml
- raised against amino acids 33-262 mapping within an internal region of MULK of human origin
- recommended for detection of MULK of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MULK Antibody (C-7) for WB applications. These reagents are now offered in bundles with MULK Antibody (C-7) (see ordering information below).
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MULK Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects MULK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MULK, also known as acylglycerol kinase (AGK), is a 422 amino acid protein localized to the mitochondrial membrane, where MULK plays a crucial role in lipid metabolism. MULK functions as a lipid kinase, phosphorylating monoacylglycerol and diacylglycerol to produce lysophosphatidic acid (LPA) and phosphatidic acid (PA). The generation of LPA is significant as LPA activates various signaling pathways, including the epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK) pathways, ultimately promoting cell proliferation. Overexpression of MULK has been linked to increased LPA production, which is implicated in the initiation and progression of prostate cancer, highlighting MULK′s potential as a therapeutic target. Additionally, MULK exists in two alternatively spliced isoforms and requires magnesium as a cofactor for enzymatic activity, further underscoring MULK′s complex regulatory mechanisms. MULK is encoded by a gene located on chromosome 7q34, making MULK a significant focus for research in cancer biology and lipid signaling. Anti-MULK antibody (C-7) provides a reliable tool for studying MULK and its role in various biological processes.
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MULK Antibody (C-7) References:
- Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells. | Spiegel, S. and Milstien, S. 2005. Biochem Soc Trans. 33: 1362-5. PMID: 16246119
- Acylglycerol Kinase: Mitochondrial Protein Transport Meets Lipid Biosynthesis. | Mårtensson, CU. and Becker, T. 2017. Trends Cell Biol. 27: 700-702. PMID: 28867158
- Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. | Hu, Z., et al. 2019. Cell Metab. 30: 290-302.e5. PMID: 31204281
- Acylglycerol kinase promotes the stemness of nasopharyngeal carcinoma cells by promoting β-catenin translocation to the nucleus through activating PI3K/Akt pathway. | Zhao, Q., et al. 2020. Environ Toxicol. 35: 1299-1307. PMID: 32652857
- Acylglycerol kinase promotes paclitaxel resistance in nasopharyngeal carcinoma cells by regulating FOXM1 via the JAK2/STAT3 pathway. | Zhao, C., et al. 2021. Cytokine. 148: 155595. PMID: 34116927
- Acylglycerol Kinase-Targeted Therapies in Oncology. | Chu, B., et al. 2021. Front Cell Dev Biol. 9: 659158. PMID: 34368119
- Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signaling pathway. | Wang, H., et al. 2022. Can J Physiol Pharmacol. 100: 142-150. PMID: 34559978
- Inhibition of acylglycerol kinase sensitizes DLBCL to venetoclax via upregulation of FOXO1-mediated BCL-2 expression. | Ning, N., et al. 2022. Theranostics. 12: 5537-5550. PMID: 35910796
- Acylglycerol kinase promotes ovarian cancer progression and regulates mitochondria function by interacting with ribosomal protein L39. | Sun, F., et al. 2022. J Exp Clin Cancer Res. 41: 238. PMID: 35934718
- Performance of ChatGPT on a Radiology Board-style Examination: Insights into Current Strengths and Limitations. | Bhayana, R., et al. 2023. Radiology. 307: e230582. PMID: 37191485
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MULK Antibody (C-7) | sc-398943 | 200 µg/ml | $322.00 | |||
MULK Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-538548 | 200 µg Ab; 10 µg BP | $361.00 | |||
MULK Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-536184 | 200 µg Ab; 40 µg BP | $361.00 | |||
MULK Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-545759 | 200 µg Ab; 20 µg BP | $361.00 |