Matrilin-4 Antibody (F-2): sc-374653
- Matrilin-4 Antibody (F-2) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 265-409 mapping within an internal region of Matrilin-4 of human origin
- Matrilin-4 Antibody (F-2) is recommended for detection of Matrilin-4 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Matrilin-4 Antibody (F-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Matrilin-4 Antibody (F-2) for WB and IHC(P) applications. These reagents are now offered in bundles with Matrilin-4 Antibody (F-2) (see ordering information below).
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Matrilin-4 Antibody (F-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects Matrilin-4 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Matrilin-4 (F-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Matrilin-4 serves as a crucial component of the extracellular matrix, particularly in cartilage, where Matrilin-4 plays a significant role in maintaining structural integrity and facilitating cellular interactions. Matrilin-4 is primarily expressed in embryonic kidney, lung, and placenta, proving vital for proper cartilage development and function. The matrilin family, including Matrilin-1 through Matrilin-4, contributes to the assembly and organization of the extracellular matrix, with anti-Matrilin-4 antibody (F-2) specifically detecting proteins involved in forming filamentous networks that support cartilage architecture. Understanding Matrilin-4 function remains essential, as disruptions in expression or function can lead to various cartilage-related disorders, highlighting Matrilin-4′s importance in both developmental biology and potential therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Matrilin-4 Antibody (F-2) References:
- The matrilins: a novel family of oligomeric extracellular matrix proteins. | Deák, F., et al. 1999. Matrix Biol. 18: 55-64. PMID: 10367731
- Expression of matrilin-1, -2 and -3 in developing mouse limbs and heart. | Segat, D., et al. 2000. Matrix Biol. 19: 649-55. PMID: 11102754
- Association analysis of genotypic frequencies of matrilin-1 gene in patients with osteoarthritis. | Strusberg, I., et al. 2002. Clin Exp Rheumatol. 20: 543-5. PMID: 12175111
- Immunohistochemical study of matrilin-1 in arthritic articular cartilage of the mandibular condyle. | Ohno, S., et al. 2003. J Oral Pathol Med. 32: 237-42. PMID: 12653864
- Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan. | Wiberg, C., et al. 2003. J Biol Chem. 278: 37698-704. PMID: 12840020
- Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease. | Hansson, AS., et al. 2004. Am J Pathol. 164: 959-66. PMID: 14982849
- Functional analysis of the regulatory regions of the matrilin-1 gene in transgenic mice reveals modular arrangement of tissue-specific control elements. | Karcagi, I., et al. 2004. Matrix Biol. 22: 605-18. PMID: 15062854
- Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias. | Mann, HH., et al. 2004. J Biol Chem. 279: 25294-8. PMID: 15075323
- Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice. | Hansson, AS., et al. 2004. Arthritis Res Ther. 6: R484-91. PMID: 15380048
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Matrilin-4 Antibody (F-2) | sc-374653 | 200 µg/ml | $322.00 | |||
Matrilin-4 Antibody (F-2): m-IgGκ BP-HRP Bundle | sc-522803 | 200 µg Ab, 40 µg BP | $361.00 | |||
Matrilin-4 Antibody (F-2): m-IgG2b BP-HRP Bundle | sc-549071 | 200 µg Ab; 10 µg BP | $361.00 | |||
Matrilin-4 Antibody (F-2) AC | sc-374653 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Matrilin-4 Antibody (F-2) HRP | sc-374653 HRP | 200 µg/ml | $322.00 | |||
Matrilin-4 Antibody (F-2) FITC | sc-374653 FITC | 200 µg/ml | $336.00 | |||
Matrilin-4 Antibody (F-2) PE | sc-374653 PE | 200 µg/ml | $349.00 | |||
Matrilin-4 Antibody (F-2) Alexa Fluor® 488 | sc-374653 AF488 | 200 µg/ml | $364.00 | |||
Matrilin-4 Antibody (F-2) Alexa Fluor® 546 | sc-374653 AF546 | 200 µg/ml | $364.00 | |||
Matrilin-4 Antibody (F-2) Alexa Fluor® 594 | sc-374653 AF594 | 200 µg/ml | $364.00 | |||
Matrilin-4 Antibody (F-2) Alexa Fluor® 647 | sc-374653 AF647 | 200 µg/ml | $364.00 | |||
Matrilin-4 Antibody (F-2) Alexa Fluor® 680 | sc-374653 AF680 | 200 µg/ml | $364.00 | |||
Matrilin-4 Antibody (F-2) Alexa Fluor® 790 | sc-374653 AF790 | 200 µg/ml | $364.00 |