Molecular structure of L-CCG-IV, CAS Number: 117857-95-1
L-CCG-IV (CAS 117857-95-1)
Alternate Names:
(2S,1′S,2′R)-2-(Carboxycyclopropyl)glycine
Application:
L-CCG-IV is a potent small molecule agonist at the NMDA receptor
CAS Number:
117857-95-1
Purity:
≥97%
Molecular Weight:
159.14
Molecular Formula:
C6H9NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-CCG-IV is a potent NMDA receptor agonist.
L-CCG-IV (CAS 117857-95-1) References
- Evaluation and comparison of ion permeation and agonist selectivities for N-methyl-d-aspartate receptor channels with different subunit compositions in bilayer lipid membranes based on integrated single-channel currents. | Hirano, A., et al. 2000. Anal Biochem. 283: 258-65. PMID: 10906247
- A single-channel method for evaluation of very magnitudes of Ca2+ ion fluxes through epsilon4/zeta1 N-methyl-D-aspartate receptor channels in bilayer lipid membranes. | Wakabayashi, M., et al. 2001. J Pharm Biomed Anal. 24: 453-60. PMID: 11199224
- 2-(Carboxycyclopropyl)glycines: binding, neurotoxicity and induction of intracellular free Ca2+ increase. | Kawai, M., et al. 1992. Eur J Pharmacol. 211: 195-202. PMID: 1319341
- Changes in preference for receptor subtypes of configurational variants of a glutamate analog: conversion from the NMDA-type to the non-NMDA type. | Ishida, M., et al. 1991. Brain Res. 550: 152-6. PMID: 1653635
- A significant increase in intracellular Ca2+ concentration induced by (2S,3R,4S)-2-(carboxycyclopropyl)glycine, a new potent NMDA agonist, in cultured rat hippocampal neurons. | Kudo, Y., et al. 1991. Brain Res. 567: 342-5. PMID: 1840131
- Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. | Vance, KM., et al. 2011. Nat Commun. 2: 294. PMID: 21522138
- A conformationally restricted analogue of L-glutamate, the (2S,3R,4S) isomer of L-alpha-(carboxycyclopropyl)glycine, activates the NMDA-type receptor more markedly than NMDA in the isolated rat spinal cord. | Shinozaki, H., et al. 1989. Brain Res. 480: 355-9. PMID: 2565750
- Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord. | Shinozaki, H., et al. 1989. Br J Pharmacol. 98: 1213-24. PMID: 2692753
- Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons. | Wilsch, VW., et al. 1994. Eur J Pharmacol. 262: 287-91. PMID: 7813594
- (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. | Nakamura, Y., et al. 1993. Neuropharmacology. 32: 833-7. PMID: 7901789
- A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord. | Ishida, M., et al. 1993. Br J Pharmacol. 109: 1169-77. PMID: 8401927
- DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice. | Uyama, Y., et al. 1997. Brain Res. 752: 327-30. PMID: 9106476
Activator of:
NMDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-CCG-IV, 1 mg | sc-203098 | 1 mg | $213.00 |