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IKKβ Antibody (10A9B6) is a mouse monoclonal IgG1 antibody that detects IKKβ in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IKKβ, a key component of the IKK complex, plays a crucial role in the activation of the transcription factor NFκB, which is essential for regulating immune responses, inflammation, and cell survival. Located primarily in the cytoplasm, IKKβ interacts with IκB proteins, facilitating their phosphorylation and subsequent degradation, which allows NFκB to translocate to the nucleus and initiate the transcription of target genes. The proper functioning of IKKβ is vital, as dysregulation can lead to various diseases, including cancer and autoimmune disorders. Additionally, IKKβ undergoes post-translational modifications, such as phosphorylation, which can influence activity and interactions with other proteins, further underscoring importance in cellular signaling pathways. Anti-IKKβ antibody (10A9B6) is an invaluable tool for researchers studying NFκB signaling and its implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IKKβ Antibody (10A9B6) | sc-56918 | 100 µg/ml | $339.00 |