HHV-6 gp116/64/54 Antibody (6A5): sc-65449

HHV-6 gp116/64/54 Antibody (6A5) is a mouse monoclonal IgG2b kappa light chain antibody that detects the glycoprotein gB, specifically gp116/64/54, of strains A and B of HHV-6 by immunoprecipitation (IP) and immunofluorescence (IF). HHV-6 gp116/64/54 (6A5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The glycoprotein gB plays a crucial role in the viral life cycle, as gB is essential for the fusion of the viral envelope with the host cell membrane, facilitating viral entry and subsequent infection. Understanding gB function is vital, as gB not only aids in the development of antiviral therapies but also serves as a target for vaccine development, given gB′s importance in the pathogenesis of HHV-6-related diseases. The Herpesviridae family, which includes HHV-6, is known for establishing latency and reactivation in various tissues, contributing to a range of clinical manifestations, including febrile illnesses and potential links to demyelinating diseases. HHV-6 infection is particularly notable for persisting in monocytes/macrophages, salivary glands, brain, and kidney, with HHV-6 DNA often detected in serum samples of patients with multiple sclerosis, indicating HHV-6′s potential role in disease exacerbation.

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HHV-6 gp116/64/54 Antibody (6A5) References:

1. The HHV6 paradox: ubiquitous commensal or insidious pathogen? A two-step in situ PCR approach.  |  Blumberg, BM., et al. 2000. J Clin Virol. 16: 159-78. PMID: 10738136
2. Human herpesvirus 6 (HHV6) infection.  |  Abdel-Haq, NM. and Asmar, BI. 2004. Indian J Pediatr. 71: 89-96. PMID: 14979393
3. Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children.  |  Caserta, MT., et al. 2004. J Pediatr. 145: 478-84. PMID: 15480370
4. Lack of association of polyomavirus and herpesvirus types 6 and 7 in human lymphomas.  |  Hernández-Losa, J., et al. 2005. Cancer. 103: 293-8. PMID: 15593086
5. Fatal pulmonary failure attributable to viral pneumonia with human herpes virus 6 (HHV6) in a young immunocompetent woman.  |  Merk, J., et al. 2005. J Intensive Care Med. 20: 302-6. PMID: 16206417
6. [Drug hypersensitivity syndrome associated with a primary HHV6 infection].  |  Debarbieux, S., et al. 2006. Ann Dermatol Venereol. 133: 145-7. PMID: 16508598
7. Human herpesvirus 6 (HHV6) and chronic fatigue syndrome (CFS).  |  Ablashi, DV., et al. 1991. Can Dis Wkly Rep. 17 Suppl 1E: 33-40. PMID: 1669351
8. Three new human herpesviruses (HHV6, 7, and 8).  |  Levy, JA. 1997. Lancet. 349: 558-63. PMID: 9048803
9. The latency rate of human herpesvirus 6 (HHV6) in positive and negative human immunodeficiency virus (HIV) infection of intravenous drug users (IVDU).  |  Jayavasu, C., et al. 1997. Asian Pac J Allergy Immunol. 15: 29-33. PMID: 9251845

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HHV-6 gp116/64/54 Antibody (6A5) has 3 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HHV-6 gp116/64/54 Antibody (6A5) Specifications

Alternate Product Name: HHV-6 gp116/64/54

Product Clone Name: 6A5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: strains A and B

Epitope Species: HHV-6

Product Reactivity/Detection: glycoprotein gB, gp116/64/54

Species Reactivity/Detection: strains A, B of HHV-6

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, IF

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for HHV-6 gp116/64/54 Antibody (6A5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin