FcRH3 Antibody (F-9): sc-365705

FcRH3 Antibody (F-9) is a mouse monoclonal IgG1 antibody that detects FcRH3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FcRH3, a member of the Fc receptor homolog (FcRH) family, plays a crucial role in the immune system by regulating the activity of marginal zone B cells, which are essential for the production of antibodies and the maintenance of immune homeostasis. FcRH3 is primarily located on the surface of these B cells, where FcRH3 modulates signaling pathways that can either enhance or inhibit immune responses, thereby influencing the body′s ability to respond to pathogens and maintain tolerance to self-antigens. The presence of immunoreceptor-tyrosine inhibitory motifs in FcRH3′s cytoplasmic domain underscores its function in dampening excessive immune activation, which is vital for preventing autoimmune diseases. Notably, mutations in the gene encoding FcRH3 have been linked to various autoimmune disorders, including systemic lupus erythematosus and rheumatoid arthritis, highlighting its importance in maintaining immune balance. Anti-FcRH3 antibody (F-9) is an invaluable tool for researchers investigating the complex mechanisms of immune regulation and the potential therapeutic targets for autoimmune diseases.

The preferred FcRH3 antibody is FcRH3 Antibody (C-2): sc-365706.