DIXDC1 Antibody (A-6): sc-377160
- DIXDC1 Antibody (A-6) is a mouse monoclonal IgG2b DIXDC1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 121-420 mapping within an internal region of DIXDC1 of human origin
- DIXDC1 Antibody (A-6) is recommended for detection of DIXDC1 isoforms 1, 2, 3 and 4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-DIXDC1 Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DIXDC1 Antibody (A-6). This work is in progress.
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DIXDC1 Antibody (A-6) is a mouse monoclonal IgG2b antibody that detects DIXDC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DIXDC1 Antibody (A-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DIXDC1, also known as DIX domain containing 1 or Dixin, is a 683 amino acid protein that plays a crucial role in cellular signaling and cytoskeletal dynamics. DIXDC1 is primarily localized to cell junctions and the cytoplasm in an isoform-dependent manner, which is significant for DIXDC1′s function in regulating the Wnt signaling pathway. This pathway is essential for various developmental processes and cellular functions, as Wnt signaling influences gene expression by targeting the β-catenin-TCF complex. DIXDC1′s interaction with F-Actin further underscores DIXDC1′s importance, as DIXDC1 acts as a positive regulator of actin dynamics, thereby contributing to the structural integrity and motility of cells. The gene encoding DIXDC1 is located on human chromosome 11, a region associated with several genetic disorders, highlighting the potential implications of DIXDC1 in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DIXDC1 Antibody (A-6) References:
- KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain. | Katoh, M. and Katoh, M. 2003. Int J Oncol. 23: 145-50. PMID: 12792787
- The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. | Wong, CK., et al. 2004. J Biol Chem. 279: 39366-73. PMID: 15262978
- Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. | Luo, W., et al. 2005. J Biol Chem. 280: 5054-60. PMID: 15579909
- DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein. | Wang, X., et al. 2006. Biochem Biophys Res Commun. 347: 22-30. PMID: 16814745
- Crystallization and preliminary X-ray crystallographic studies of the axin DIX domain. | Shibata, N., et al. 2007. Acta Crystallogr Sect F Struct Biol Cryst Commun. 63: 529-31. PMID: 17554179
- DIXDC1 promotes retinoic acid-induced neuronal differentiation and inhibits gliogenesis in P19 cells. | Jing, XT., et al. 2009. Cell Mol Neurobiol. 29: 55-67. PMID: 18629627
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DIXDC1 Antibody (A-6) | sc-377160 | 200 µg/ml | $322.00 | |||
DIXDC1 Antibody (A-6) AC | sc-377160 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DIXDC1 Antibody (A-6) HRP | sc-377160 HRP | 200 µg/ml | $322.00 | |||
DIXDC1 Antibody (A-6) FITC | sc-377160 FITC | 200 µg/ml | $336.00 | |||
DIXDC1 Antibody (A-6) PE | sc-377160 PE | 200 µg/ml | $349.00 | |||
DIXDC1 Antibody (A-6) Alexa Fluor® 488 | sc-377160 AF488 | 200 µg/ml | $364.00 | |||
DIXDC1 Antibody (A-6) Alexa Fluor® 546 | sc-377160 AF546 | 200 µg/ml | $364.00 | |||
DIXDC1 Antibody (A-6) Alexa Fluor® 594 | sc-377160 AF594 | 200 µg/ml | $364.00 | |||
DIXDC1 Antibody (A-6) Alexa Fluor® 647 | sc-377160 AF647 | 200 µg/ml | $364.00 | |||
DIXDC1 Antibody (A-6) Alexa Fluor® 680 | sc-377160 AF680 | 200 µg/ml | $364.00 | |||
DIXDC1 Antibody (A-6) Alexa Fluor® 790 | sc-377160 AF790 | 200 µg/ml | $364.00 |