DDX17 Antibody (B-6): sc-376297
- DDX17 Antibody (B-6) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 561-591 within an internal region of DDX17 of human origin
- recommended for detection of DDX17 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for DDX17 Antibody (B-6) for WB applications. This reagent is now offered in a bundle with DDX17 Antibody (B-6) (see ordering information below).
DDX17 Antibody (B-6) is a mouse monoclonal IgG3 antibody that detects DDX17 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DDX17, also known as DEAD box protein 17 or p72, plays a crucial role in various cellular processes, particularly in RNA metabolism regulation. DDX17 is primarily located in the nucleus and cytoplasm, where DDX17 functions as an RNA helicase, unwinding RNA structures to facilitate essential processes such as translation initiation and splicing. Proper localization of DDX17 is vital for function, ensuring interaction with RNA substrates and other cellular machinery effectively. Dysregulation of DDX17 has been linked to significant developmental issues, including impairments in early brain development that can lead to conditions such as Down Syndrome. Furthermore, aberrant expression of DDX17 has been associated with colon cancer progression, highlighting DDX17′s potential as a therapeutic target. Anti-DDX17 antibody (B-6) is an invaluable tool for researchers investigating DDX17′s roles in various biological contexts and disease states.
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DDX17 Antibody (B-6) References:
- Functions of DEAD box RNA helicases DDX5 and DDX17 in chromatin organization and transcriptional regulation. | Giraud, G., et al. 2018. BMB Rep. 51: 613-622. PMID: 30293550
- DDX17 promotes hepatocellular carcinoma progression via inhibiting Klf4 transcriptional activity. | Xue, Y., et al. 2019. Cell Death Dis. 10: 814. PMID: 31653828
- RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis. | Ngo, TD., et al. 2019. Cell Rep. 29: 4024-4035.e5. PMID: 31851931
- Human DDX17 Unwinds Rift Valley Fever Virus Non-Coding RNAs. | Nelson, CR., et al. 2020. Int J Mol Sci. 22: PMID: 33374561
- DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner. | Fortuna, TR., et al. 2021. Acta Neuropathol. 142: 515-536. PMID: 34061233
- Move over NAIP, DDX17 diversifies the NLRC4 inflammasome. | Barnett, KC., et al. 2021. Sci Immunol. 6: eabm1201. PMID: 34860580
- DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. | Wang, SB., et al. 2021. Sci Immunol. 6: eabi4493. PMID: 34860583
- DDX17 identified as inflammasome sensor for retrotransposon RNA. | Minton, K. 2022. Nat Rev Immunol. 22: 73. PMID: 34876701
- DDX17 modulates the expression and alternative splicing of genes involved in apoptosis and proliferation in lung adenocarcinoma cells. | He, C., et al. 2022. PeerJ. 10: e13895. PMID: 36164607
- MTDH-stabilized DDX17 promotes tumor initiation and progression through interacting with YB1 to induce EGFR transcription in Hepatocellular Carcinoma. | Jin, C., et al. 2023. Oncogene. 42: 169-183. PMID: 36385375
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DDX17 Antibody (B-6) | sc-376297 | 200 µg/ml | $322.00 | |||
DDX17 Antibody (B-6): m-IgG3 BP-HRP Bundle | sc-550455 | 200 µg Ab; 40 µg BP | $361.00 | |||
DDX17 (B-6) Neutralizing Peptide | sc-376297 P | 100 µg/0.5 ml | $69.00 |