Cytokeratin 18 Antibody (RCK106): sc-32722

Cytokeratin 18 Antibody (RCK106) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 18 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Cytokeratin 18 is a vital component of the cytoskeleton in epithelial cells, contributing significantly to their structural integrity and resilience. Anti-Cytokeratin 18 antibody (RCK106) recognizes a protein predominantly located in the cytoplasm, where Cytokeratin 18 forms a network of intermediate filaments that provide mechanical support and shape to cells. Proper localization of Cytokeratin 18 is crucial for maintaining epithelial tissue architecture, and disruption can lead to various pathological conditions, including cancer. Cytokeratin 18 serves as a biomarker for epithelial-derived tumors, as expression levels can indicate malignant cell differentiation status. Cytokeratin 18 undergoes post-translational modifications, including phosphorylation, which influences protein interactions and cellular function. Phosphorylation of specific serine residues, such as Ser 33 and Ser 52, is particularly important for Cytokeratin 18 stability and interaction with 14-3-3 proteins, which regulate keratin organization and distribution. Cytokeratin 18 monoclonal antibody (RCK106) enables researchers to gain valuable insights into normal physiology and disease states, enhancing understanding of epithelial biology and tumor pathology.

The preferred Cytokeratin 18 antibody is Cytokeratin 18 Antibody (RGE53): sc-32329.