Cytokeratin 10/13 Antibody (4A28): sc-70908
- Cytokeratin 10/13 Antibody (4A28) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against Cytoskeletal preparation extracted from human ectocervical epithelium
- recommended for detection of Cytokeratin 10 and Cytokeratin 13 of human origin by WB, IP, IF and IHC(P); specific for Cytokeratin 13 by IHC(P)
- See Cytokeratin 10 (LH2): sc-53252 for Cytokeratin 10/13 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Cytokeratin 10/13 Antibody (4A28) for WB and IHC(P) applications. These reagents are now offered in bundles with Cytokeratin 10/13 Antibody (4A28) (see ordering information below).
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Cytokeratin 10/13 Antibody (4A28) is a mouse monoclonal IgG2a antibody that detects Cytokeratin 10/13 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Cytokeratin 10 and 13 are crucial components of the cytoskeletal structure in epithelial cells, contributing to mechanical resilience and tissue integrity. Cytokeratin 10 and 13 are primarily located in the cytoplasm of epithelial cells, providing structural support and playing a vital role in cellular differentiation and tissue specialization. Expression patterns of Cytokeratin 10 and 13 are particularly significant in cancer, serving as important biomarkers for identifying and characterizing malignant tumors. Presence of Cytokeratin 10 and 13 is often associated with squamous cell carcinomas, while absence can indicate a shift towards a more aggressive tumor phenotype. Understanding Cytokeratin 10 and 13 localization and function aids in carcinoma diagnosis and enhances knowledge of epithelial cell biology and tumor progression mechanisms. Anti-Cytokeratin 10/13 antibody (4A28) serves as an invaluable tool for researchers and clinicians exploring epithelial tissue dynamics and cancer pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cytokeratin 10/13 Antibody (4A28) References:
- Cytokeratin 10 and cytokeratin 19: predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection. | Yang, XR., et al. 2008. Clin Cancer Res. 14: 3850-9. PMID: 18559605
- Cytokeratin 10-negative nested pattern enables sure distinction of clonal seborrheic keratosis from pagetoid Bowen's disease. | Böer-Auer, A., et al. 2012. J Cutan Pathol. 39: 225-33. PMID: 22236073
- Cytokeratin 13 contains O-glycosidically linked N-acetylglucosamine residues. | King, IA. and Hounsell, EF. 1989. J Biol Chem. 264: 14022-8. PMID: 2474541
- Synthesis of cytokeratin 13, a component characteristic of internal stratified epithelia, is not induced in human epidermal tumors. | Kuruc, N., et al. 1989. Differentiation. 42: 111-23. PMID: 2483837
- Cytokeratin 13, Cytokeratin 17, Ki-67 and p53 Expression in Upper Layers of Epithelial Dysplasia Surrounding Tongue Squamous Cell Carcinoma. | Matsuhira, A., et al. 2015. Bull Tokyo Dent Coll. 56: 223-31. PMID: 26657521
- Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity. | Hamed, MA., et al. 2017. Clin Exp Otorhinolaryngol. 10: 213-220. PMID: 28073243
- Proteomic profiles and cytokeratin 13 as a potential biomarker of Ovis aries papillomavirus 3-positive and negative cutaneous squamous cell carcinomas. | Vitiello, V., et al. 2021. Res Vet Sci. 134: 112-119. PMID: 33360571
- Allantodapsone is a Pan-Inhibitor of Staphylococcus aureus Adhesion to Fibrinogen, Loricrin, and Cytokeratin 10. | Prencipe, F., et al. 2022. Microbiol Spectr. 10: e0117521. PMID: 35647689
- The increased expression of cytokeratin 13 leads to an increase in radiosensitivity of nasopharyngeal carcinoma HNE-3 cells by upregulating ERRFI1. | Wang, H., et al. 2023. IUBMB Life. 75: 688-698. PMID: 37070291
- Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis. | Porter, RM., et al. 1996. J Cell Biol. 132: 925-36. PMID: 8603923
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 10/13 Antibody (4A28) | sc-70908 | 200 µg/ml | $322.00 | |||
Cytokeratin 10/13 Antibody (4A28): m-IgG Fc BP-HRP Bundle | sc-539320 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cytokeratin 10/13 Antibody (4A28): m-IgG2a BP-HRP Bundle | sc-546691 | 200 µg Ab; 10 µg BP | $361.00 |