CTP Antibody (C-12): sc-518244

CTP Antibody (C-12) is a mouse monoclonal IgA kappa light chain antibody specific for an epitope mapping between amino acids 102-129 of CTP of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CTP monoclonal antibody (C-12) is available in a non-conjugated form, designed for versatile applications in research. Citrate transport protein (CTP), also known as Tricarboxylate transport protein, or SLC25A1, is a crucial 311 amino acid mitochondrial multi-pass membrane protein that plays a vital role in transporting citrate across the mitochondrial inner membrane. This transport is essential as citrate serves as a key carbon source for the biosynthesis of sterols and fatty acids, thereby significantly influencing the bioenergetics of hepatic cells. The importance of CTP is underscored by involvement in various metabolic pathways, and alterations in function have been linked to conditions such as type I diabetes and certain cancers. Additionally, the gene encoding CTP is located in a chromosomal region often deleted in patients with DiGeorge syndrome, a disorder that leads to immune deficiencies and other serious health issues. CTP is predominantly expressed in adult tissues such as the ovary, gut, liver, and testis, as well as in fetal organs including the kidney, lung, brain, and liver, highlighting a critical role in both development and metabolism. These characteristics make anti-CTP antibody (C-12) a valuable tool for investigating mitochondrial citrate transport and impact on metabolic pathways and cellular bioenergetics.

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CTP Antibody (C-12) References:

1. Kinetic evidence for the uniport mechanism hypothesis in the mitochondrial tricarboxylate transport system.  |  De Palma, A., et al. 2005. J Bioenerg Biomembr. 37: 279-87. PMID: 16341772
2. Conjugated linoleic acid and hepatic lipogenesis in mouse: role of the mitochondrial citrate carrier.  |  Ferramosca, A., et al. 2006. J Lipid Res. 47: 1994-2003. PMID: 16816327
3. The mitochondrial citrate transport protein: evidence for a steric interaction between glutamine 182 and leucine 120 and its relationship to the substrate translocation pathway and identification of other mechanistically essential residues.  |  Ma, C., et al. 2006. Biochim Biophys Acta. 1757: 1271-6. PMID: 16904062
4. The yeast mitochondrial citrate transport protein: identification of the Lysine residues responsible for inhibition mediated by Pyridoxal 5'-phosphate.  |  Remani, S., et al. 2008. J Bioenerg Biomembr. 40: 577-85. PMID: 19002576
5. Probing the effect of transport inhibitors on the conformation of the mitochondrial citrate transport protein via a site-directed spin labeling approach.  |  Mayor, JA., et al. 2010. J Bioenerg Biomembr. 42: 99-109. PMID: 20354774
6. The yeast mitochondrial citrate transport protein: molecular determinants of its substrate specificity.  |  Aluvila, S., et al. 2010. J Biol Chem. 285: 27314-27326. PMID: 20551333
7. Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein.  |  Jiang, L., et al. 2017. Metab Eng. 43: 198-207. PMID: 27856334
8. The mitochondrial tricarboxylate transport protein. cDNA cloning, primary structure, and comparison with other mitochondrial transport proteins.  |  Kaplan, RS., et al. 1993. J Biol Chem. 268: 13682-90. PMID: 8514800
9. Cloning, genomic organization, and chromosomal localization of human citrate transport protein to the DiGeorge/velocardiofacial syndrome minimal critical region.  |  Goldmuntz, E., et al. 1996. Genomics. 33: 271-6. PMID: 8660975
10. Localization of the human mitochondrial citrate transporter protein gene to chromosome 22Q11 in the DiGeorge syndrome critical region.  |  Heisterkamp, N., et al. 1995. Genomics. 29: 451-6. PMID: 8666394
11. The human mitochondrial citrate transporter gene (SLC20A3) maps to chromosome band 22q11 within a region implicated in DiGeorge syndrome, velo-cardio-facial syndrome and schizophrenia.  |  Stoffel, M., et al. 1996. Hum Genet. 98: 113-5. PMID: 8682495
12. Organization and sequence of the human gene for the mitochondrial citrate transport protein.  |  Iacobazzi, V., et al. 1997. DNA Seq. 7: 127-39. PMID: 9254007

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CTP Antibody (C-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CTP Antibody (C-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CTP Antibody (C-12) Specifications

Alternate Product Name: CTP

Product Clone Name: C-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids: 102-129

Epitope Target: CTP

Epitope Species: human

Product Reactivity/Detection: CTP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CTP Antibody (C-12): N/A