cortistatin Antibody (A-7): sc-393108
- cortistatin Antibody (A-7) is a mouse monoclonal IgG1 κ cortistatin antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 1-105 mapping at the N-terminus of cortistatin of human origin
- cortistatin Antibody (A-7) is recommended for detection of cortistatin of human origin by WB, IP, IF and ELISA
- Anti-cortistatin Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for cortistatin Antibody (A-7) for WB applications. These reagents are now offered in bundles with cortistatin Antibody (A-7) (see ordering information below).
QUICK LINKS
SEE ALSO...
Cortistatin Antibody (A-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects cortistatin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-cortistatin antibody (A-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cortistatin, a 155 amino acid neuropeptide encoded by the human CORT gene, plays a crucial role in regulating neuronal activity and sleep patterns. Cortistatin is primarily located in the central nervous system, where cortistatin is involved in modulating slow-wave sleep and reducing locomotor activity. This localization highlights cortistatin′s potential as a therapeutic target for sleep disorders and other neurological conditions. Cortistatin′s ability to bind to all known somatostatin receptors allows cortistatin to share many functional properties with somatostatin, yet cortistatin also exhibits unique effects, such as inducing slow-wave sleep through antagonism of acetylcholine′s excitatory effects on the cortex. This multifaceted role underscores cortistatin′s importance in neurophysiological processes and relevance in research and clinical applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cortistatin Antibody (A-7) References:
- Processing of rat preprocortistatin in mouse AtT-20 cells. | Puebla, L., et al. 1999. J Neurochem. 73: 1273-7. PMID: 10461921
- Fine mapping of the human preprocortistatin gene (CORT) to neuroblastoma consensus deletion region 1p36.3-->p36.2, but absence of mutations in primary tumors. | Ejeskär, K., et al. 2000. Cytogenet Cell Genet. 89: 62-6. PMID: 10894940
- Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. | Spier, AD. and de Lecea, L. 2000. Brain Res Brain Res Rev. 33: 228-41. PMID: 11011067
- Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells. | Dalm, VA., et al. 2003. Am J Physiol Endocrinol Metab. 285: E344-53. PMID: 12684217
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. | Clark, HF., et al. 2003. Genome Res. 13: 2265-70. PMID: 12975309
- Identification and characterization of a novel human cortistatin-like peptide. | Fukusumi, S., et al. 1997. Biochem Biophys Res Commun. 232: 157-63. PMID: 9125122
- Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. | de Lecea, L., et al. 1997. Genomics. 42: 499-506. PMID: 9205124
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cortistatin Antibody (A-7) | sc-393108 | 200 µg/ml | $322.00 | |||
cortistatin Antibody (A-7): m-IgG Fc BP-HRP Bundle | sc-527669 | 200 µg Ab; 10 µg BP | $361.00 | |||
cortistatin Antibody (A-7): m-IgG1 BP-HRP Bundle | sc-533042 | 200 µg Ab; 20 µg BP | $361.00 | |||
cortistatin Antibody (A-7) AC | sc-393108 AC | 500 µg/ml, 25% agarose | $424.00 | |||
cortistatin Antibody (A-7) HRP | sc-393108 HRP | 200 µg/ml | $322.00 | |||
cortistatin Antibody (A-7) FITC | sc-393108 FITC | 200 µg/ml | $336.00 | |||
cortistatin Antibody (A-7) PE | sc-393108 PE | 200 µg/ml | $349.00 | |||
cortistatin Antibody (A-7) Alexa Fluor® 488 | sc-393108 AF488 | 200 µg/ml | $364.00 | |||
cortistatin Antibody (A-7) Alexa Fluor® 546 | sc-393108 AF546 | 200 µg/ml | $364.00 | |||
cortistatin Antibody (A-7) Alexa Fluor® 594 | sc-393108 AF594 | 200 µg/ml | $364.00 | |||
cortistatin Antibody (A-7) Alexa Fluor® 647 | sc-393108 AF647 | 200 µg/ml | $364.00 | |||
cortistatin Antibody (A-7) Alexa Fluor® 680 | sc-393108 AF680 | 200 µg/ml | $364.00 | |||
cortistatin Antibody (A-7) Alexa Fluor® 790 | sc-393108 AF790 | 200 µg/ml | $364.00 |