Coronin 1B Antibody (E-3): sc-271375
- Coronin 1B Antibody (E-3) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against amino acids 390-489 mapping at the C-terminus of Coronin 1B of human origin
- recommended for detection of Coronin 1B of human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Coronin 1B Antibody (E-3) for WB applications. This reagent is now offered in a bundle with Coronin 1B Antibody (E-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Coronin 1B Antibody (E-3) is a mouse monoclonal IgM antibody that detects Coronin 1B in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Coronin 1B plays a crucial role in regulating cell motility and cytoskeletal dynamics, particularly in fibroblasts, where Coronin 1B is involved in the phosphorylation process mediated by protein kinase C at Serine 2. This post-translational modification is essential as Coronin 1B influences the dynamics at the leading edge of the cell, thereby affecting how cells move and respond to their environment. The ability of anti-Coronin 1B antibody (E-3) to interact with the Arp2/3 complex further underscores Coronin 1B′s importance in orchestrating actin polymerization and cellular movement. By utilizing Coronin 1B (E-3) antibody, researchers can gain insights into the mechanisms of cell motility and the underlying processes that contribute to various physiological and pathological conditions, making anti-Coronin 1B antibody (E-3) a valuable tool for studies in cell biology and related fields.
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Coronin 1B Antibody (E-3) References:
- Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. | Cai, L., et al. 2005. J Biol Chem. 280: 31913-23. PMID: 16027158
- Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. | Cai, L., et al. 2007. Cell. 128: 915-29. PMID: 17350576
- Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. | Cai, L., et al. 2008. Cell. 134: 828-42. PMID: 18775315
- WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility. | Howell, M., et al. 2015. J Cell Biol. 208: 961-74. PMID: 25800056
- Coronin 1B Reorganizes the Architecture of F-Actin Networks for Contractility at Steady-State and Apoptotic Adherens Junctions. | Michael, M., et al. 2016. Dev Cell. 37: 58-71. PMID: 27046832
- Coronin 1B serine 2 phosphorylation by p38α is critical for vascular endothelial growth factor-induced migration of human umbilical vein endothelial cells. | Kim, GY., et al. 2016. Cell Signal. 28: 1817-1825. PMID: 27592029
- Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II. | Priya, R., et al. 2016. Cell Cycle. 15: 3033-3041. PMID: 27650961
- Binding of coronin 1B to TβRI negatively regulates the TGFβ1 signaling pathway. | Kim, GY., et al. 2017. Biochem Biophys Res Commun. 490: 574-579. PMID: 28625921
- Coronin 1B regulates the TNFα-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD. | Kim, GY., et al. 2020. Biochem Biophys Res Commun. 526: 999-1004. PMID: 32303335
- Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis. | Hachimi, M., et al. 2021. Curr Biol. 31: 696-706.e9. PMID: 33275893
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Coronin 1B Antibody (E-3) | sc-271375 | 200 µg/ml | $322.00 | |||
Coronin 1B Antibody (E-3): m-IgGκ BP-HRP Bundle | sc-521921 | 200 µg Ab, 40 µg BP | $361.00 |