Anti-COP1 Anticorpo B-12é um anticorpo monoclonal produzido em camundongo IgG1 κ COP1 anticorpo, citado em 4 publicações, fornecido em 200 µg/ml
raised against amino acids 432-731 mapping at the C-terminus of COP1 of human origin
Anti-COP1 Anticorpo (B-12) é recomendado para a detecção de COP1 de mouse, rat e human origem em WB, IP, IF, IHC(P) e ELISA
Anti-COP1 Antibody (B-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
dispnonível como reagente TransCruz para o uso em ChIP (sc-166799 X, 200 µg/0.1 ml)
Entre em contato conosco e receba GRATUITAMENTE um amostra de 10 µg de COP1 (B-12): sc-166799.
m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for COP1 Antibody (B-12) for WB and IHC(P) applications. These reagents are now offered in bundles with COP1 Antibody (B-12) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
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COP1 Antibody (B-12) is a high quality monoclonal COP1 antibody (also designated COP1 antibody) suitable for the detection of the COP1 protein of mouse, rat and human origin. COP1 Antibody (B-12) is available as both the non-conjugated anti-COP1 antibody form, as well as multiple conjugated forms of anti-COP1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. COP1 (Constitutive photomorphogenesis protein 1), also designated RFWD2 (ring finger and WD repeat domain 2) or RNF200 (ring finger protein 200), is an E3 ubiquitin ligase protein that mediates ubiquitination and degradation of target proteins such as c-Jun and p53. It is a component of the DCX DET1-COP1 ubiquitin ligase complex which consists of RBX1, DET1, DDB1, CUL4A and COP1. Localizing to the cytoplasm and to the nucleus, COP1 is primarily expressed in testis, placenta, heart and skeletal muscle. COP1 is a potent inhibitor of p53-dependent transcription and apoptosis but, when phosphorylated by Atm (ataxia telangiectasia mutated) in response to DNA damage, the COP1-p53 complex is disrupted and p53 is allowed to exert its pro-apoptotic properties. In ovarian and breast cancers, COP1 is overexpressed, suggesting a role for COP1 in tumorigenesis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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