CLEC-1 Antibody (E-1): sc-390005

CLEC-1 Antibody (E-1) is a mouse monoclonal IgG1 antibody that detects CLEC-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CLEC-1, a member of the C-type lectin-like receptor family, is a crucial player in the immune system, particularly in the recognition and response to pathogens. This 280 amino acid type II transmembrane protein is predominantly expressed in dendritic and endothelial cells, where CLEC-1 plays a vital role in antigen uptake and processing. CLEC-1′s unique structure includes a single carbohydrate recognition domain, which is essential for function in binding to specific carbohydrate structures on pathogens, thereby facilitating immune responses. Additionally, CLEC-1 contains a cytoplasmic immuno-receptor tyrosine-based motif and numerous potential phosphorylation sites, which are critical for downstream signaling pathways that regulate immune cell activation and function. The proper localization of CLEC-1 in perinuclear compartments is also significant, as CLEC-1 requires an associated chain for transport to the cell surface, ensuring availability for interaction with antigens. Anti-CLEC-1 antibody (E-1) enables researchers to gain insights into the mechanisms of innate immunity and the role of CLEC-1 in immune responses, making anti-CLEC-1 antibody (E-1) an invaluable tool for studies in immunology and related fields.

The preferred CLEC-1 antibody is CLEC-1 Antibody (D-6): sc-393134.