Cdx2 Anticorpo B-3é um anticorpo monoclonal produzido em camundongo IgG1 κ, citado em 4 publicações, fornecido em 200 µg/ml
raised against amino acids 271-313 mapping at the C-terminus of Cdx2 of human origin
recomendado para a detecção de Cdx2 of human origin by WB, IP, IF and ELISA
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Cdx2 Antibody (B-3) for WB applications. These reagents are now offered in bundles with Cdx2 Antibody (B-3) (see ordering information below).
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Labware ships FedEx Ground free of charge to the contiguous US
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The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are members of the caudal-type homeobox family of genes, which are homologues of the Drosophila ′caudal′ gene required for anterior-posterior regional identity. The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation. Cdx1 positively regulates its own expression. Cdx1 and Cdx2 are expressed in the small intestine and colon of fetus and adult. A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis, and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways. The human Cdx1 gene maps to chromosome 5q32 and encodes a 265-amino acid protein.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.