CD5 Antibody (Y2/178): sc-53206

CD5 Antibody (Y2/178) is a mouse monoclonal IgG1 antibody that detects CD5 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD5 is a crucial transmembrane glycoprotein predominantly expressed on T lymphocytes, where CD5 plays a significant role in modulating T cell activation and survival. Located on the surface of these immune cells, CD5 interacts with the T cell receptor (TCR) and the CD3-ζ chain, facilitating a complex signaling cascade that is essential for T cell function. Notably, CD5 phosphorylation upon TCR engagement enhances the activity of the Src family kinase Lck, which is vital for T cell signaling. CD5 expression is also linked to the regulation of T cell responses, as CD5 absence can lead to hyper-responsiveness to TCR-mediated activation, potentially resulting in autoimmune conditions. Furthermore, CD5′s interaction with the B cell antigen CD72 suggests a role in thymic selection, although the exact consequences of this binding remain an area of active research. Anti-CD5 antibody (Y2/178) is an invaluable tool for studying T cell biology and the intricate mechanisms of immune regulation.

The preferred CD5 antibody is CD5 Antibody (UCH-T2): sc-1180.