CD1D Antibody (G-10): sc-271340
- CD1D Antibody (G-10) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 71-140 mapping near the N-terminus of CD1D of human origin
- recommended for detection of CD1D of human origin by WB, IP, IF and ELISA
- See CD1D (C3D5): sc-19632 for CD1D antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD1D Antibody (G-10) for WB applications. These reagents are now offered in bundles with CD1D Antibody (G-10) (see ordering information below).
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CD1D Antibody (G-10) is a mouse monoclonal IgG2a antibody that detects CD1D in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CD1D antibody (G-10) targets CD1D protein, which plays a crucial role in the immune system by presenting lipid antigens to T lymphocytes, thereby influencing T cell activation and maturation. CD1D protein is primarily located on the surface of various immune cells, including intestinal epithelial cells, where CD1D exists in both β-2-Microglobulin-independent and β-2-Microglobulin-dependent forms. CD1D expression on these cells is vital for the recognition of lipid antigens, which can lead to the activation of specific T cell responses, particularly in mucosal immunity. The human CD1D gene, located on chromosome 1q23.1, encodes a 335 amino acid protein that is essential for the development of CD1-restricted T cells, highlighting CD1D′s importance in maintaining immune homeostasis and responding to lipid-based pathogens.
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CD1D Antibody (G-10) References:
- CD1d-restricted glycolipid antigens: presentation principles, recognition logic and functional consequences. | Florence, WC., et al. 2008. Expert Rev Mol Med. 10: e20. PMID: 18601810
- NKT TCR recognition of CD1d-α-C-galactosylceramide. | Patel, O., et al. 2011. J Immunol. 187: 4705-13. PMID: 21964029
- Recognition of CD1d-restricted antigens by natural killer T cells. | Rossjohn, J., et al. 2012. Nat Rev Immunol. 12: 845-57. PMID: 23154222
- CD1d and natural killer T cells in immunity to Mycobacterium tuberculosis. | Arora, P., et al. 2013. Adv Exp Med Biol. 783: 199-223. PMID: 23468111
- The Response of CD1d-Restricted Invariant NKT Cells to Microbial Pathogens and Their Products. | Van Kaer, L., et al. 2015. Front Immunol. 6: 226. PMID: 26029211
- CD1d Expression and Invariant NKT Cell Responses in Herpesvirus Infections. | Chung, BK., et al. 2015. Front Immunol. 6: 312. PMID: 26161082
- The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions. | Macho-Fernandez, E. and Brigl, M. 2015. Front Immunol. 6: 362. PMID: 26284062
- Epigenetic control of CD1D expression as a mechanism of resistance to immune checkpoint therapy in poorly immunogenic melanomas. | Wang, MM., et al. 2023. Front Immunol. 14: 1152228. PMID: 37077920
- CD1d-dependent neuroinflammation impairs tissue repair and functional recovery following a spinal cord injury. | Wu, X., et al. 2023. bioRxiv.. PMID: 37905092
- Ox-LDL-induced CD80+ macrophages expand pro-atherosclerotic NKT cells via CD1d in atherosclerotic mice and hyperlipidemic patients. | Wang, Y., et al. 2024. Am J Physiol Cell Physiol. 326: C1563-C1572. PMID: 38586879
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD1D Antibody (G-10) | sc-271340 | 200 µg/ml | $322.00 | |||
CD1D Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-537616 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD1D Antibody (G-10): m-IgGκ BP-HRP Bundle | sc-534933 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD1D Antibody (G-10): m-IgG2a BP-HRP Bundle | sc-548068 | 200 µg Ab; 10 µg BP | $361.00 |