Caprin1 Antibody (G-10): sc-518252
- Caprin1 Antibody (G-10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 191-217 of Caprin1 of human origin
- recommended for detection of Caprin1 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Caprin1 Antibody (G-10) for WB applications. This reagent is now offered in a bundle with Caprin1 Antibody (G-10) (see ordering information below).
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Caprin1 Antibody (G-10) is a mouse monoclonal IgG1 antibody specific for an epitope mapping between amino acids 191-217 of Caprin1 of human origin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Caprin1 is a 709 amino acid protein that plays a crucial role in regulating the transport and translation of mRNAs associated with synaptic plasticity and cellular proliferation, making Caprin1 vital for proper neuronal function and development. Caprin1 is predominantly localized in the cytoplasm, cytosol, and cell projections, which is significant as Caprin1′s localization is essential for involvement in mRNA metabolism and the formation of ribonucleoprotein complexes. Caprin1 is known to interact with several key proteins, including G3BP1, CaMKIIα, and BDNF, and may form homomultimeric structures that facilitate regulatory functions. The gene encoding Caprin1 is located on human chromosome 11, a region implicated in various genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome, highlighting Caprin1′s importance in both health and disease. anti-Caprin1 antibody (G-10) is an invaluable tool for researchers studying the molecular mechanisms underlying these processes and the associated pathologies.
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Caprin1 Antibody (G-10) References:
- Upregulation of caprin1 expression is associated with poor prognosis in hepatocellular carcinoma. | Tan, N., et al. 2017. Pathol Res Pract. 213: 1563-1567. PMID: 29037839
- Role of caprin-1 in carcinogenesis. | Yang, ZS., et al. 2019. Oncol Lett. 18: 15-21. PMID: 31289466
- LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation. | Wang, R., et al. 2021. Sci Adv. 7: PMID: 33762340
- CAPRIN1 Enhances Chemoresistance and Glycolysis in Laryngeal Squamous Cell Carcinoma via Regulation of ZIC5. | Zhang, Y., et al. 2022. J Oncol. 2022: 6160539. PMID: 35571493
- Mapping the per-residue surface electrostatic potential of CAPRIN1 along its phase-separation trajectory. | Toyama, Y., et al. 2022. Proc Natl Acad Sci U S A. 119: e2210492119. PMID: 36040869
- CAPRIN1P512L causes aberrant protein aggregation and associates with early-onset ataxia. | Delle Vedove, A., et al. 2022. Cell Mol Life Sci. 79: 526. PMID: 36136249
- STRESS granule-associated RNA-binding protein CAPRIN1 drives cancer progression and regulates treatment response in nasopharyngeal carcinoma. | Yang, T., et al. 2022. Med Oncol. 40: 47. PMID: 36515758
- Expression of GADD45G and CAPRIN1 in Human Nucleus Pulposus: Implications for Intervertebral Disc Degeneration. | Kawaguchi, K., et al. 2023. Int J Mol Sci. 24: PMID: 36982840
- CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma. | Kurhade, C., et al. 2023. mBio. 14: e0017223. PMID: 37052473
- Atomic resolution map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates. | Ahmed, R., et al. 2024. Proc Natl Acad Sci U S A. 121: e2408554121. PMID: 39172789
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caprin1 Antibody (G-10) | sc-518252 | 200 µg/ml | $322.00 | |||
Caprin1 Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-551705 | 200 µg Ab; 10 µg BP | $361.00 |