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C8 Ceramide-1-phosphate (CAS 887353-95-9)

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Alternate Names:
N-[2-Hydroxy-1-[(phosphonooxy)methyl]-3-heptadecen-1-yl]octanamide;N-Octanoylsphingosine-1-phosphate
Application:
C8 Ceramide-1-phosphate is A chemical that stimulates the synthesis of DNA
CAS Number:
887353-95-9
Molecular Weight:
505.67
Molecular Formula:
C26H52NO6P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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C8 Ceramide-1-phosphate (CAS 887353-95-9) is a synthetic analog of naturally occurring ceramide-1-phosphate (C1P), a lipid molecule that plays a significant role in cellular signaling, particularly in the regulation of cell growth, differentiation, and survival. This specific molecule is characterized by an eight-carbon acyl chain (C8), distinguishing it from the longer chains typically found in naturally derived ceramides. This shorter chain length affects the biophysical properties of the lipid, such as its solubility and membrane dynamics, making it a useful tool in research. C8 Ceramide-1-phosphate is primarily utilized in studies investigating the mechanisms of lipid-mediated signaling. The phosphate group in its structure is pivotal, as it confers a negative charge, influencing interactions with proteins and other cell components. In experimental settings, researchers employ C8 Ceramide-1-phosphate to explore its impact on various cellular processes such as apoptosis and inflammation. By manipulating levels of this ceramide in cellular or animal models, insights into how ceramide-1-phosphate influences signaling pathways and cellular behavior can be gleaned. Additionally, its use helps in understanding the role of lipid signaling molecules in maintaining cellular homeostasis and response to environmental stresses, offering a precise method to probe the complex interactions within lipid signaling networks.


C8 Ceramide-1-phosphate (CAS 887353-95-9) References

  1. Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters.  |  Jasinska, R., et al. 1999. Biochem J. 340 (Pt 3): 677-86. PMID: 10359651
  2. Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase.  |  Benaud, C., et al. 2002. J Biol Chem. 277: 10539-46. PMID: 11792696
  3. Sphingomyelinase and ceramide analogs induce vasoconstriction and leukocyte-endothelial interactions in cerebral venules in the intact rat brain: Insight into mechanisms and possible relation to brain injury and stroke.  |  Altura, BM., et al. 2002. Brain Res Bull. 58: 271-8. PMID: 12128152
  4. Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate.  |  Högback, S., et al. 2003. Biochem J. 370: 111-9. PMID: 12416995
  5. Ceramide 1-phosphate enhances calcium entry through voltage-operated calcium channels by a protein kinase C-dependent mechanism in GH4C1 rat pituitary cells.  |  Törnquist, K., et al. 2004. Biochem J. 380: 661-8. PMID: 15018614
  6. A ceramide-1-phosphate analogue, PCERA-1, simultaneously suppresses tumour necrosis factor-alpha and induces interleukin-10 production in activated macrophages.  |  Goldsmith, M., et al. 2009. Immunology. 127: 103-15. PMID: 18793216
  7. Ceramide-1-phosphate, a new mediator of development and survival in retina photoreceptors.  |  Miranda, GE., et al. 2011. Invest Ophthalmol Vis Sci. 52: 6580-8. PMID: 21724910
  8. Complex modulation of peptidolytic activity of cathepsin D by sphingolipids.  |  Zebrakovská, I., et al. 2011. Biochim Biophys Acta. 1811: 1097-104. PMID: 21964280
  9. Anti-inflammatory mechanism of exogenous C2 ceramide in lipopolysaccharide-stimulated microglia.  |  Jung, JS., et al. 2013. Biochim Biophys Acta. 1831: 1016-26. PMID: 23384839
  10. Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides.  |  Gomez-Muñoz, A., et al. 1995. Mol Pharmacol. 47: 833-9. PMID: 7746276

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

C8 Ceramide-1-phosphate, 1 mg

sc-207388
1 mg
$268.00