beta-Lapachone CAS: 4707-32-8
MF: C15H14O3
MW: 242.27
A selective DNA topoisomerase I inhibitor.

β-Lapachone (CAS 4707-32-8)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 134ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
5
1
4
0
3
0
2
0
1
0
Sinônimo 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Aplicação A selective DNA topoisomerase I inhibitor
Numero VAT: 4707-32-8
Privada: ≥98%
Peso Molecular: 242.27
Separar por Funcao: C15H14O3
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
Faça a sua avaliação desse produto e receba 15 CruzCredits

β-Lapachone, a novel Topo I (topoisomerase I) inhibitor, does not stabilize the cleavable complex indicating a novel mode of action, unlike camptothecin (sc-200871). Apoptosis has been demonstrated in HL-60 and human prostate cancer cells treated with β-Lapachone via a p53-independent mechanism and cell cycle arrest at G0/G1,2. β-Lapachone has been observed to accelerate wound healing by increasing cell proliferation in cells such as: keratinocytes, fibroblasts and endothelial while also increasing the migration of fibroblasts and endothelial cells. β-Lapachone has exhibited anti-inflammatory properties by suppressing the NF-κB activation by blocking IκBα degradation and downregulating the ERK, p38 mitogen-activated protein kinase and Akt pathway.


Referencias

1. Planchon, S M., et al., 1995. Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response. Cancer research. 55(17): 3706-11. PMID: 7641180
2. Li, C J., et al., 1993. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. The Journal of biological chemistry. 268(30): 22463-8. PMID: 8226754
3. Choi, Byung Tae., et al., 2003. beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells. Anti-cancer drugs. 14(10): 845-50. PMID: 14597880
4. Moon, Dong-Oh., et al., 2007. Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia. International immunopharmacology. 7(4): 506-14. PMID: 17321474
5. Kung, Hsiu-Ni., et al., 2008. In vitro and in vivo wound healing-promoting activities of beta-lapachone. American journal of physiology. Cell physiology. 295(4): C931-43. PMID: 18650264
6. Dong, Guang Zhi., et al., 2010. Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB. Experimental & molecular medicine. 42(5): 327-34. PMID: 20200474

Paginas :
Store, as supplied, at room temperature for up to 1 year. Store solutions at - 20°C for up to 3 months.
Estado físico :
Solid
envie :
Soluble in DMSO (>25 mg/ml), ethanol (20 mg/ml), chloroform, and DMF.
Manutencao :
Store at -20° C
Ponto de fusão :
~151-153° C (dec.)
Ponto de fervura :
~381.4° C at 760 mmHg (Predicted)
Densidade :
1.25 g/cm3 (Predicted)
Indice de produtos :
n20D 1.60
Reatividade :
α20/D -43.9°, c = 2 in water
IC50 :
HIV-1 LTR: IC50 = 0.3 µM (human); HOS: IC50 = 1400 nM (human); MDA-MB-435 : IC50 = 0.06 ug.mL-1 (human); HL-60: IC50 = 1650 nM (human)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
RTECS :
QL6127400
PubChem CID :
3885
Numero de FAX :
MFCD01712233
Registro Beilstein :
0181499
SMILES :
CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C

Baixar SDS (MSDS)

Certificado de Análise

É necessário o Adobe Acrobat Reader para visualizar corretamente,
imprimir e comentar os documentos PDF

beta-Lapachone  Citacoes dos Produtos

Visualizar com outras pessoas usaram beta-Lapachone. Clique em PubMed para ver .

Citações 1 para 6 de 6 total

PMID: # 17609380  Bey, EA. et al. 2007. Proc. Natl. Acad. Sci. USA. 104: 11832-11837.

PMID: # 15044484  Lin, MT et al. 2004. J Biol Chem. 279: 24015-23.

PMID: # 12598645  Li, Y. et al. 2003. Proc. Natl. Acad. Sci. U.S.A. 100: 2674-2678.

PMID: # 9927052  Shiah, SG. et al. 1999. Cancer Res. 59: 391-398.

PMID: # 9927052  Shiah, SG. et al. 1999. Cancer Res. 59: 391-398.

PMID: # 2740334  Boothman, DA. et al. 1989. Proc. Natl. Acad. Sci. U.S.A. 86: 4963-4967.

Citações 1 para 6 de 6 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 121ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

A Santa Cruz Biotecnologia, Inc. é a líder mundial no desenvolvimento de produtos para o mercado de pesquisa biomédica. Ligue para nós ligação gratuita 1-800-457-3801..
Direito de Reprodução© 2007-2020 Santa Cruz Biotechnology, Inc. Todos os direitos reservados. "Santa Cruz Biotechnology", Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", "EZ Touch" são marcas registradas da Santa Cruz Biotechnology, Inc. Todas as marcas registradas são propriedade dos seus respectivos donos.