beta-cyano-L-Alanine CAS: 6232-19-5
MF: C4H6N2O2
MW: 114.1
A reversible inhibitor of the H2S-synthesizing enzyme cystathionine γ lyase.

β-cyano-L-Alanine (CAS 6232-19-5)

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Nomes alternativos: BCA
Aplicação β-cyano-L-Alanine is a reversible inhibitor of the H2S-synthesizing enzyme cystathionine γ lyase
Numero VAT: 6232-19-5
Peso Molecular: 114.1
Separar por Funcao: C4H6N2O2
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).

β-cyano-L-Alanine (BCA) is a reversible inhibitor of the H2S-synthesizing enzyme CTH (CSE). BCA blocks H2S synthesis activity in rat liver preparations with an IC50 value of 6.5 μM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H2S synthesis. BCA at 50 mg/kg blocked both L-cysteine- and LPS-induced hyperalgesia in rats. Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity. H2S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, CTH (cystathionine γ lyase CSE) and cystathionineβ synthetase (CBS).


Referencias

1 Li, L., Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air?. Trends Pharmacol Sci 29(2) 84-90 (2007). 2 Wang, R. Two's company, three's a crowd: Can H2S be the third endogenous gaseous transmitter?. FASEB J 16(13) 1792-1798 (2002). 3 Pfeffer, M., Ressler, C. b-cyanoalanine, an inhibitor of rat liver cystathionase. Biochem Pharmacol 16 2299-2308 (1967). 4 Mok, Y.P., Atan, M.S.B.M., Ping, C.Y., et al. Role of hydrogen sulphide in haemorrhagic shock in the rat: Protective effect of inhibitors of hydrogen sulphide biosynthesis. Br J Pharmacol 143 881-889 (2004). 5 Kawabata, A., Ishiki, T., Nagasawa, K., et al. Hydrogen sulfide as a novel nociceptive messenger. Pain 132 74-81 (2008).

Estado físico :
Solid
envie :
Soluble in water (10 mg/ml), ethanol, DMSO, DMF, and PBS (pH 7.2) (~10 mg/ml).
Manutencao :
Store at -20° C
Ponto de fusão :
217° C
Ponto de fervura :
~368.1° C at 760 mmHg (Predicted)
Densidade :
~1.3 g/cm3 (Predicted)
Indice de produtos :
n20D 1.50 (Predicted)
IC50 :
Blocks H2S synthesis: IC50 = 6.5 µM (rat liver preparations)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
PubChem CID :
Numero de FAX :
MFCD00021722
SMILES :
C(C#N)[[email protected]@H](C(=O)O)N

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