AOS-1 Antibody (G-3): sc-376146
- AOS-1 Antibody (G-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 65-101 near the N-terminus of AOS-1 of human origin
- recommended for detection of AOS-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, bovine and porcine
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for AOS-1 Antibody (G-3) for WB applications. This reagent is now offered in a bundle with AOS-1 Antibody (G-3) (see ordering information below).
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AOS-1 Antibody (G-3) is a mouse monoclonal IgG1 antibody that detects AOS-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AOS-1, also known as SUMO-1-activating enzyme or ubiquitin-like 1-activating enzyme E1A, is a crucial component of the ubiquitin-like (UBL) conjugation pathway, specifically functioning as a ubiquitin-activating E1 ligase. AOS-1 plays a vital role in the activation of UBL1, which is essential for various cellular processes, including cell cycle regulation and stress response mechanisms. AOS-1 operates as a dimeric enzyme, facilitating the ATP-dependent activation of UBL1, and can form heterodimers with UBLE1A and UBLE1B, enhancing functional capacity. Proper functioning of AOS-1 is critical, as disruptions in the UBL conjugation pathway can lead to various diseases, including cancer and neurodegenerative disorders. Anti-AOS-1 antibody (G-3) enables researchers to gain valuable insights into the dynamics of protein degradation and the regulatory mechanisms that govern cellular homeostasis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AOS-1 Antibody (G-3) | sc-376146 | 200 µg/ml | $322.00 | |||
AOS-1 Antibody (G-3): m-IgG Fc BP-HRP Bundle | sc-540521 | 200 µg Ab; 10 µg BP | $361.00 | |||
AOS-1 (G-3) Neutralizing Peptide | sc-376146 P | 100 µg/0.5 ml | $69.00 |