α-sarcoglycan Antibody (C-12): sc-515255

α-sarcoglycan Antibody (C-12) is a mouse monoclonal IgG2a antibody that detects α-sarcoglycan in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). α-sarcoglycan is a crucial component of the dystrophin-associated protein complex, primarily located in the cell membrane of skeletal, cardiac, and smooth muscle fibers, where α-sarcoglycan plays a vital role in maintaining the structural integrity of muscle cells. α-sarcoglycan interacts with other sarcoglycan subunits—β-, γ-, and δ-sarcoglycan—to form a stable complex that is essential for muscle function. Disruption of this complex due to genetic mutations can lead to severe muscle disorders, including sarcoglycanopathy, an autosomal recessive muscular dystrophy characterized by muscle weakness and degeneration. α-sarcoglycan′s importance extends beyond structural roles, as α-sarcoglycan is also involved in signaling pathways that regulate muscle cell survival and repair. α-sarcoglycan Antibody (C-12) provides a reliable tool for researchers studying muscle pathologies and the underlying mechanisms of sarcoglycan-related diseases, facilitating advancements in therapeutic strategies.

The preferred α-sarcoglycan antibody is α-sarcoglycan Antibody (D-7): sc-271321.