Almorexant (CAS 871224-64-5)
Alternate Names:
2(1H)-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluorom ethyl)phenyl]ethyl]-, (αR,1S)-
CAS Number:
871224-64-5
Molecular Weight:
512.57
Molecular Formula:
C29H31F3N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Almorexant (CAS 871224-64-5) References
- Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant. | Dietrich, H. and Jenck, F. 2010. Psychopharmacology (Berl). 212: 145-54. PMID: 20631993
- Differential effects of the dual orexin receptor antagonist almorexant and the GABA(A)-α1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat. | Steiner, MA., et al. 2011. Neuropsychopharmacology. 36: 848-56. PMID: 21150905
- The brain orexin system and almorexant in fear-conditioned startle reactions in the rat. | Steiner, MA., et al. 2012. Psychopharmacology (Berl). 223: 465-75. PMID: 22592903
- The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. | Srinivasan, S., et al. 2012. PLoS One. 7: e44726. PMID: 23028593
- The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors. | Mang, GM., et al. 2012. Sleep. 35: 1625-35. PMID: 23204605
- Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy. | Black, SW., et al. 2013. Sleep. 36: 325-36. PMID: 23449602
- The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats. | Morairty, SR., et al. 2014. Front Neurosci. 8: 3. PMID: 24550767
- The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems. | Parks, GS., et al. 2016. Neuropsychopharmacology. 41: 1144-55. PMID: 26289145
- The dual orexin receptor antagonist almorexant blocks the sleep-disrupting and daytime stimulant effects of methamphetamine in rhesus monkeys. | Berro, LF., et al. 2021. Drug Alcohol Depend. 227: 108930. PMID: 34358767
- Effect of different doses of almorexant on learning and memory in 8-month-old APP/PS1 (AD) mice. | Zhou, M. and Li, Y. 2023. Peptides. 167: 171044. PMID: 37330110
Inhibitor of:
Orexin, Orexin R-1, Orexin R-2, pro-MCH, and QRFP.Activator of:
EMR2, and Olr22.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Almorexant, 10 mg | sc-507322 | 10 mg | $330.00 |