AF-10 Antibody (HAF10 10D3/8): sc-53155

AF-10 Antibody (HAF10 10D3/8) is a mouse monoclonal IgG2a antibody that detects AF-10 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP). AF-10 is a crucial nuclear protein that plays a significant role in transcription regulation and is implicated in the t(10;11) translocation associated with acute myeloid leukemia, highlighting AF-10′s importance in cancer biology. AF-10 consists of 1,027 amino acids in humans, exhibiting a remarkable 90% sequence identity with mouse AF-10, which contains 1,061 amino acids. AF-10 is primarily expressed in the testis, where AF-10 may influence spermatogenesis and other reproductive processes. AF-10′s structural features, including conserved domains that facilitate protein-protein interactions, are essential for AF-10′s function as a transcription factor. Understanding AF-10′s structure is vital, as such knowledge can provide insights into regulatory mechanisms and potential therapeutic targets in leukemia and other malignancies. Anti-AF-10 antibody (HAF10 10D3/8) serves as an invaluable tool for researchers investigating AF-10′s role in various biological contexts.

The preferred AF-10 antibody is AF-10 Antibody (HAF10 9A5/2): sc-53156.