7-Hydroxyaristolochic acid A CAS: 79185-75-4
MF: C17H11NO8
MW: 357.27
An aristolochic acid associated with urothelial carcinoma formation.

7-Hydroxyaristolochic acid A (CAS 79185-75-4)

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Nomes alternativos: 6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
Aplicação 7-Hydroxyaristolochic acid A is an aristolochic acid associated with urothelial carcinoma formation
Numero VAT: 79185-75-4
Peso Molecular: 357.27
Separar por Funcao: C17H11NO8
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).

7-Hydroxyaristolochic acid A is an aristolochic acid. These compounds are the active ingredients, responsible for the hepatoxicity and renal toxicity, found in Aristolochic fangchi. They form DNA adducts in renal tissue and are associated with urothelial carcinoma formation.


Referencias

1. Pfau, W., et al., 1990. 32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II. Carcinogenesis. 11(9): 1627-33. PMID: 2401053
2. Rossiello, M R., et al., 1993. Induction of hepatic nodules in the rat by aristolochic acid. Cancer letters. 71(1-3): 83-7. PMID: 8364902
3. Mengs, U., et al., 1993. Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology. Archives of toxicology. 67(5): 307-11. PMID: 8368940
4. Hadjiolov, D., et al., 1993. Effect of diallyl sulfide on aristolochic acid-induced forestomach carcinogenesis in rats. Carcinogenesis. 14(3): 407-10. PMID: 8453716
5. Schmeiser, H H., et al., 1996. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer research. 56(9): 2025-8. PMID: 8616845
6. Levi, M., et al., 1998. Acute hepatitis in a patient using a Chinese herbal tea--a case report. Pharmacy world & science : PWS. 20(1): 43-4. PMID: 9536471
7. Nortier, J L., et al., 2000. Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi) The New England journal of medicine. 342(23): 1686-92. PMID: 10841870

Estado físico :
Solid
envie :
Soluble in water.
Manutencao :
Store at -20° C
Ponto de fusão :
287-292° C
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
PubChem CID :
SMILES :
COC1=C(C=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O)O

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