20S Proteasome β1 Antibody (MCP421): sc-58409
- 20S Proteasome β1 Antibody (MCP421) is a mouse monoclonal IgG1, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against dinitrophenylated proteasomes of human origin
- recommended for detection of 20S Proteasome β1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for 20S Proteasome β1 Antibody (MCP421). This work is in progress.
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20S Proteasome β1 Antibody (MCP421) is a mouse monoclonal IgG1 antibody that detects 20S Proteasome β1 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. 20S Proteasome β1 is a crucial component of the 26S proteasome complex, which plays a vital role in maintaining cellular homeostasis by degrading unnecessary or damaged proteins. 20S Proteasome β1 is primarily located within the cytoplasm and nucleus of eukaryotic cells, where 20S Proteasome β1 forms part of the 20S core particle that houses the proteolytic activity essential for protein turnover. Proper functioning of the proteasome is critical, as proteasome activity regulates various cellular processes, including the cell cycle, apoptosis, and responses to oxidative stress. Dysregulation of proteasomal activity can lead to the accumulation of damaged proteins, contributing to various diseases, including neurodegenerative disorders and cancer. The 20S Proteasome β1 subunit is involved in the catalytic activity of the proteasome, and expression levels can serve as a biomarker for proteasome function in different pathological conditions. Anti-20S Proteasome β1 antibody (MCP421) is an invaluable tool for researchers studying proteasome dynamics and their implications in health and disease.
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20S Proteasome β1 Antibody (MCP421) References:
- Cloning and molecular characterization of a gene encoding a Cryptosporidium parvum putative 20S proteasome beta1-type subunit. | Chung, PA., et al. 2000. DNA Seq. 11: 309-14. PMID: 11092745
- Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1. | Fan, J., et al. 2004. Acta Biochim Biophys Sin (Shanghai). 36: 42-6. PMID: 14732874
- Growth-associated protein of 43 kDa (GAP-43) is cleaved nonprocessively by the 20S proteasome. | Denny, JB. 2004. Eur J Biochem. 271: 2480-93. PMID: 15182364
- PRS3 encoding an essential subunit of yeast proteasomes homologous to mammalian proteasome subunit C5. | Lee, DH., et al. 1992. Biochem Biophys Res Commun. 182: 452-60. PMID: 1734860
- A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. | Long, P., et al. 2012. Eur J Neurosci. 36: 2733-42. PMID: 22779921
- Inhibition on Proteasome β1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer Cells. | Li, D., et al. 2015. PLoS One. 10: e0141681. PMID: 26512898
- Proteasome Subunit Beta Type 1 P11A Polymorphism Is a New Prognostic Marker in Multiple Myeloma. | Varga, G., et al. 2017. Clin Lymphoma Myeloma Leuk. 17: 734-742. PMID: 28733196
- Phenoxypropanolamine derivatives as selective inhibitors of the 20S proteasome β1 and β5 subunits. | Hovhannisyan, AA., et al. 2017. Bioorg Med Chem Lett. 27: 5172-5178. PMID: 29113763
- Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins. | Abi Habib, J., et al. 2020. Sci Rep. 10: 15765. PMID: 32978409
- MG132 protects against lung injury following brain death in rats. | Shi, H., et al. 2022. Exp Ther Med. 24: 687. PMID: 36277154
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
20S Proteasome β1 Antibody (MCP421) | sc-58409 | 50 µg/0.5 ml | $322.00 |