TFR2 Ativadores

Os activadores comuns do TFR2 incluem, entre outros, o cloreto de cobalto(II) CAS 7646-79-9, o sulfato de cobre(II) CAS 7758-98-7, o ácido L-ascórbico, ácido livre CAS 50-81-7, o dietilestilbestrol CAS 56-53-1 e a dimetiloxaloilglicina (DMOG) CAS 89464-63-1.

Transferrin receptor 2 (TFR2) is a membrane-bound protein that plays a significant role in iron homeostasis, a critical process for the maintenance of cellular and systemic iron levels. TFR2 is primarily expressed in the liver and erythroid precursor cells, where it functions in concert with other proteins to regulate iron uptake and storage. Unlike its counterpart, transferrin receptor 1 (TFR1), which is ubiquitously expressed and directly involved in iron uptake by cells through the binding and internalization of transferrin-bound iron, TFR2 does not seem to play a major role in iron uptake. Instead, it has a crucial function in sensing body iron levels and modulating the activity of key regulatory proteins involved in iron metabolism, such as hepcidin. Hepcidin is a liver-produced hormone that controls iron absorption from the diet and iron release from macrophages. TFR2's interaction with hepcidin illustrates its integral role in the feedback loop that maintains iron homeostasis, ensuring that iron levels are sufficient for erythropoiesis and other physiological needs while curbing iron overload.

The activation of TFR2 is intricately linked to its ability to sense and respond to circulating iron levels, primarily through its interaction with transferrin-bound iron and its cooperation with other iron-regulatory proteins. The mechanisms of TFR2 activation involve the binding of diferric transferrin (transferrin with two iron atoms) to TFR2, which triggers signaling pathways that influence hepcidin expression. This interaction is thought to be critical in the liver's response to iron status, with TFR2 acting as a sensor for transferrin saturation and modulating hepcidin levels accordingly. Additionally, TFR2's function and activation are influenced by its oligomerization state and its interaction with other membrane proteins, including HFE (a protein associated with hereditary hemochromatosis) and transferrin receptor 1. These interactions are essential for the fine-tuning of hepcidin expression and the subsequent regulation of iron metabolism. Understanding the mechanisms underlying TFR2 activation and its role in iron homeostasis provides valuable insights into the complex regulatory networks controlling iron absorption and distribution, which are crucial for erythropoiesis and overall physiological balance.