Date published: 2025-9-10

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GP78-1 Inibidores

GP78-1 inhibitors represent a specific chemical class of compounds designed to target the protein GP78-1, also known as RNF45. GP78-1 is an E3 ubiquitin ligase responsible for regulating protein quality control and degradation processes within the cell. Inhibiting GP78-1 activity is an area of active research to gain insights into the molecular pathways that govern protein degradation. These inhibitors are meticulously developed to interact with GP78-1 at a molecular level, with the aim of modulating its enzymatic function. By specifically disrupting GP78-1's activity, researchers seek to elucidate its role in cellular protein homeostasis and degradation.

The chemical structures of GP78-1 inhibitors can vary, and they are designed to interact with specific binding sites or domains of GP78-1, thus interfering with its ability to tag proteins for degradation. Investigating GP78-1 inhibitors is an essential endeavor to advance our understanding of the complex cellular mechanisms that govern protein turnover and ensure cellular integrity. Such research contributes to the broader knowledge of cellular processes and their regulation, with implications for various biological and disease-related contexts.

VEJA TAMBÉM

Nome do ProdutoCAS #Numero de CatalogoQuantidadePrecoUso e aplicacaoNOTAS

Eeyarestatin I

412960-54-4sc-358130B
sc-358130
sc-358130A
sc-358130C
sc-358130D
sc-358130E
5 mg
10 mg
25 mg
50 mg
100 mg
500 mg
$112.00
$199.00
$347.00
$683.00
$1336.00
$5722.00
12
(1)

Este composto inibe a ERAD interferindo com a p97/VCP, um componente chave na via em que a GP78 está envolvida.

Stat3 Inhibitor VI, S3I-201

501919-59-1sc-204304
10 mg
$148.00
104
(1)

Este inibidor UBE2N pode perturbar a atividade de conjugação da ubiquitina, afectando indiretamente a função da GP78.

Clotrimazole

23593-75-1sc-3583
sc-3583A
100 mg
1 g
$41.00
$56.00
6
(2)

Conhecido como um inibidor da ATPase p97/VCP, o clotrimazol poderia influenciar os processos ERAD mediados pela GP78.

DBeQ

177355-84-9sc-499943
10 mg
$330.00
1
(0)

O DBeQ é um inibidor seletivo de p97/VCP, com potencial impacto na via ERAD onde o GP78 opera.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Um inibidor do proteassoma que pode afetar os processos a jusante da atividade da ubiquitina ligase da GP78.

NMS-873

1418013-75-8sc-478803
5 mg
$300.00
(0)

O NMS-873, um potente inibidor da p97/VCP, poderia afetar indiretamente a função da GP78 na ERAD.

Lactacystin

133343-34-7sc-3575
sc-3575A
200 µg
1 mg
$165.00
$575.00
60
(2)

Um inibidor do proteassoma, que afecta a via da ubiquitina-proteassoma, influenciando assim indiretamente a GP78.

Carfilzomib

868540-17-4sc-396755
5 mg
$40.00
(0)

Outro inibidor do proteasoma, com potencial impacto na via que envolve a GP78.