Molecular structure of Zofenopril Acyl-β-D-glucuronide
Zofenopril Acyl-β-D-glucuronide
Application:
Zofenopril Acyl-β-D-glucuronide is a metabolite of Zofenopril
Molecular Weight:
605.68
Molecular Formula:
C28H31NO10S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Zofenopril Acyl--D-glucuronide is a metabolite of Zofenopril. Zenopril is an antioxidant that acts as an angiotensin-converting enzyme (ACE) inhibitor. Studies indicate that Zenopril increases the calcium cycling of sarcoplasmic reticulum and enhances active calcium uptake into the sarcoplasmic reticulum. The compounds Zenopril and Captopril are suggested to be the only ACE inhibitors that structurally have sulphydryl groups (SH). Zenopril has been reported to to convert into Zofeniprilate, the active free sulfhydryl compound, after metabolic hydrolysis. Additional Zofenopril metabolites include: Zofenoprilat-d5 (sc-220412)
Zofenopril Acyl-β-D-glucuronide References
- Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. | Dal Bo, L., et al. 2000. J Chromatogr B Biomed Sci Appl. 749: 287-94. PMID: 11145066
- A review of the angiotensin-converting enzyme inhibitor, zofenopril, in the treatment of cardiovascular diseases. | Borghi, C., et al. 2004. Expert Opin Pharmacother. 5: 1965-77. PMID: 15330734
- Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. | Kalender, AM., et al. 2009. J Brachial Plex Peripher Nerve Inj. 4: 6. PMID: 19508704
- Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. | Frascarelli, S., et al. 2009. J Cardiovasc Pharmacol. 54: 456-63. PMID: 19738489
- Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2. | Cialdai, C., et al. 2010. Naunyn Schmiedebergs Arch Pharmacol. 382: 455-61. PMID: 20848272
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zofenopril Acyl-β-D-glucuronide, 1 mg | sc-220407 | 1 mg | $430.00 |