Zanamivir Amine (CAS 130525-62-1)

Zanamivir Amine is a derivative of zanamivir, distinguished by the substitution of an amine group in place of the guanidino group found in the parent compound. This structural modification makes Zanamivir Amine a significant compound in scientific research, especially in the study of the biochemistry and pharmacology of neuraminidase inhibitors. In biochemical research, Zanamivir Amine is used to investigate the mechanisms of action of neuraminidase inhibitors. Neuraminidase is an enzyme on the surface of the influenza virus crucial for helping the virus release from the host cell by cleaving sialic acid residues. By studying inhibitors like Zanamivir Amine, researchers can understand how changes in inhibitor structure affect interaction with neuraminidase. This helps in mapping the enzyme′s active site and identifying key interactions essential for binding. Zanamivir Amine is particularly useful in exploring how structural modifications influence binding affinity and inhibitory potency against neuraminidase. These studies are essential for understanding how different functional groups contribute to the efficacy of binding to the neuraminidase active site. Additionally, Zanamivir Amine plays a role in the development of prodrugs. The amine group offers a site for chemical modifications, enabling the synthesis of compounds that can be modified to enhance certain properties like solubility or permeability before being converted into the active form.