Z-VRPR-FMK (CAS 1217481-41-8 (free base))
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Alternate Names:
MALT1 Inhibitor
Application:
Z-VRPR-FMK is a selective cell permeable and irreversible MALT1 inhibitor
CAS Number:
1217481-41-8 (free base)
Purity:
≥90%
Molecular Weight:
790.80
Molecular Formula:
C31H49FN10O6•C2HF3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Z-VRPR-FMK is a selective cell permeable and irreversible MALT1 inhibitor. It inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Z-VRPR-FMK is shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei.
Z-VRPR-FMK (CAS 1217481-41-8 (free base)) References
- The proteolytic activity of the paracaspase MALT1 is key in T cell activation. | Rebeaud, F., et al. 2008. Nat Immunol. 9: 272-81. PMID: 18264101
- Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma. | Hailfinger, S., et al. 2009. Proc Natl Acad Sci U S A. 106: 19946-51. PMID: 19897720
- A two-step activation mechanism of MALT1 paracaspase. | Staal, J. and Beyaert, R. 2012. J Mol Biol. 419: 1-3. PMID: 22426126
- Targeting lymphomas through MALT1 inhibition. | Fontan, L. and Melnick, A. 2012. Oncotarget. 3: 1493-4. PMID: 23455603
- Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas. | Eitelhuber, AC., et al. 2015. Chem Biol. 22: 129-38. PMID: 25556945
- Detection of recombinant and cellular MALT1 paracaspase activity. | Nagel, D. and Krappmann, D. 2015. Methods Mol Biol. 1280: 239-46. PMID: 25736752
- Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Positively Modulates Matrix Metalloproteinase-9 Production in Alveolar Macrophages upon Toll-Like Receptor 7 Signaling and Influenza Virus Infection. | Lee, YH., et al. 2017. Front Immunol. 8: 1177. PMID: 29018444
- The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition. | Bardet, M., et al. 2018. Immunol Cell Biol. 96: 81-99. PMID: 29359407
- Peptide-based covalent inhibitors of MALT1 paracaspase. | Hatcher, JM., et al. 2019. Bioorg Med Chem Lett. 29: 1336-1339. PMID: 30954428
- Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. | Feng, J., et al. 2019. Int J Clin Exp Pathol. 12: 1947-1955. PMID: 31934017
- Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity. | Hughes, N., Erbel, P., Bornancin, F., Wiesmann, C., Schiering, N., Villard, F.,.. & Renatus, M. (2020). Advanced Therapeutics,. 3(9),: 2000078.
- The Paracaspase MALT1 Acts Independently of Pre-B-Cell Receptor Signaling As a Key Factor in Leukemic Cell Survival in Precursor B-Cell Acute Lymphoblastic Leukemia | NS Saba, J Meyers, L Fontan, A Melnick, A Wiestner… - Blood, 2019 - Elsevier. 13 November 2019,. Blood. Volume 134, Supplement 1,: Page 1288.
Inhibitor of:
MALT1, and NF kappa B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Z-VRPR-FMK, 500 µg | sc-396657 | 500 µg | $288.00 |