Molecular structure of YM 750, CAS Number: 138046-43-2
YM 750 (CAS 138046-43-2)
Application:
YM 750 is an acyl-CoA:cholesterol acyltransferase inhibitor
CAS Number:
138046-43-2
Purity:
≥98%
Molecular Weight:
452.63
Molecular Formula:
C31H36N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
YM 750 is reported to act as a SOAT (acyl-CoA:cholesterol acyltransferase, ACAT) inhibitor. ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A. Inhibition of ACAT can lead to various effects, including reduced cholesterol ester formation, decreased foam cell formation, altered cellular lipid homeostasis, modulation of lipoprotein profiles, and the inhibition of the progression of atherosclerotic plaques. YM 750 exhibits hypocholesterolaemic and antiatherosclerotic activity.
YM 750 (CAS 138046-43-2) References
- Bioavailable acyl-CoA: cholesterol acyltransferase inhibitor with anti-peroxidative activity: synthesis and biological activity of novel indolinyl amide and urea derivatives. | Kamiya, S., et al. 2000. Chem Pharm Bull (Tokyo). 48: 817-27. PMID: 10866142
- Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells. | Miike, T., et al. 2008. Life Sci. 82: 79-84. PMID: 18037448
- N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]- (2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme a:cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. | Nagata, Y., et al. 1995. Biochem Pharmacol. 49: 643-51. PMID: 7887979
Inhibitor of:
SOAT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
YM 750, 10 mg | sc-358844 | 10 mg | $138.00 | |||
YM 750, 50 mg | sc-358844A | 50 mg | $587.00 |