Wnt-11 Antibody (C-7): sc-365033

Wnt-11 Antibody (C-7) is a mouse monoclonal IgG3 antibody that detects Wnt-11 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Wnt-11 plays a crucial role in developmental processes, particularly in regulating cell movements during gastrulation, which is essential for proper embryonic development. Wnt-11 is primarily located in the tips of ureteric buds and the perichondrium, a stem cell-like layer that surrounds future bones, guiding their growth and regeneration. The precise expression of Wnt-11 in these areas highlights its importance in orchestrating the complex interactions necessary for tissue formation and morphogenesis. Notably, Wnt-11 is also expressed in various other tissues, including the lung mesenchyme and the cortex of the adrenal gland, but is absent in the neuroepithelium of the central nervous system, indicating a specialized role in non-neural tissues. The gene encoding Wnt-11 is located on human chromosome 11q13.5, further emphasizing its significance in human development and potential implications in various diseases when dysregulated. Anti-Wnt-11 antibody (C-7) is an invaluable tool for researchers studying the intricate pathways of cell signaling and development.

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Wnt-11 Antibody (C-7) References:

1. Opposing roles of WNT-5A and WNT-11 in interleukin-1beta regulation of type II collagen expression in articular chondrocytes.  |  Ryu, JH. and Chun, JS. 2006. J Biol Chem. 281: 22039-22047. PMID: 16754689
2. Wnt-11 signaling leads to down-regulation of the Wnt/beta-catenin, JNK/AP-1 and NF-kappaB pathways and promotes viability in the CHO-K1 cells.  |  Railo, A., et al. 2008. Exp Cell Res. 314: 2389-99. PMID: 18572162
3. Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression.  |  Nagy, II., et al. 2010. Cardiovasc Res. 85: 100-9. PMID: 19622544
4. Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells.  |  Uysal-Onganer, P., et al. 2010. Mol Cancer. 9: 55. PMID: 20219091
5. Wnt-11 and Fz7 reduce cell adhesion in convergent extension by sequestration of PAPC and C-cadherin.  |  Kraft, B., et al. 2012. J Cell Biol. 198: 695-709. PMID: 22908314
6. Clinical significance of Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer.  |  Wei, H., et al. 2014. Med Oncol. 31: 933. PMID: 24737009
7. Upregulated Wnt-11 and miR-21 Expression Trigger Epithelial Mesenchymal Transition in Aggressive Prostate Cancer Cells.  |  Arisan, ED., et al. 2020. Biology (Basel). 9: PMID: 32182839
8. Inhibition on JNK Mimics Silencing of Wnt-11 Mediated Cellular Response in Androgen-Independent Prostate Cancer Cells.  |  Arisan, ED., et al. 2020. Biology (Basel). 9: PMID: 32605008
9. Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development.  |  Christiansen, JH., et al. 1995. Mech Dev. 51: 341-50. PMID: 7547479
10. Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips.  |  Kispert, A., et al. 1996. Development. 122: 3627-37. PMID: 8951078

The preferred Wnt-11 antibody is Wnt-11 Antibody (C-8): sc-365032.