WNK4 Antibody (1E6): sc-293369
- WNK4 Antibody (1E6) is a mouse monoclonal IgG1 κ WNK4 antibody provided at 100 µg/ml
- raised against amino acids 1144-1243 of WNK4 of human origin
- recommended for detection of WNK4 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for WNK4 Antibody (1E6). This work is in progress.
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WNK4 Antibody (1E6) is a mouse monoclonal IgG1 kappa light chain antibody that detects WNK4 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-WNK4 antibody (1E6) is available as the non-conjugated format. WNK4, a member of the WNK kinase family, plays a crucial role in regulating ion transport and blood pressure homeostasis, making WNK4 significant in cardiovascular health and renal function. Located primarily in the kidney, WNK4 is involved in signaling pathways that control sodium and potassium balance, which are essential for maintaining electrolyte homeostasis. Dysregulation of WNK4 can lead to conditions such as hypertension and other renal disorders, highlighting WNK4′s importance in both physiological and pathological processes. WNK4 consists of 1,243 amino acids and shares a high degree of homology with other WNK kinases, particularly WNK1, WNK2, and WNK3, which underscores the evolutionary conservation of WNK4′s function. Aberrant activity of WNK4 and associated pathways can result in increased renal salt reabsorption and impaired excretion of potassium and hydrogen ions, further emphasizing the need for precise detection and study of WNK4 in research and clinical settings.
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WNK4 Antibody (1E6) References:
- WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. | Xu, B., et al. 2000. J Biol Chem. 275: 16795-801. PMID: 10828064
- Human hypertension caused by mutations in WNK kinases. | Wilson, FH., et al. 2001. Science. 293: 1107-12. PMID: 11498583
- WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. | Veríssimo, F. and Jordan, P. 2001. Oncogene. 20: 5562-9. PMID: 11571656
- Human hypertension caused by mutations in WNK kinases. | Hollenberg, NK. 2002. Curr Hypertens Rep. 4: 267. PMID: 12166403
- Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. | Xu, BE., et al. 2002. J Biol Chem. 277: 48456-62. PMID: 12374799
- Compilation and characterization of a novel WNK family of protein kinases in Arabiodpsis thaliana with reference to circadian rhythms. | Nakamichi, N., et al. 2002. Biosci Biotechnol Biochem. 66: 2429-36. PMID: 12506983
- WNK kinases regulate thiazide-sensitive Na-Cl cotransport. | Yang, CL., et al. 2003. J Clin Invest. 111: 1039-45. PMID: 12671053
- Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. | Tobin, MD., et al. 2005. Circulation. 112: 3423-9. PMID: 16301342
- WNK4-SPAK modulates lipopolysaccharide-induced macrophage activation. | Hung, CM., et al. 2020. Biochem Pharmacol. 171: 113738. PMID: 31786261
- WNK4 kinase: role of chloride sensing in the distal convoluted tubule. | Chen, JC., et al. 2021. Curr Opin Nephrol Hypertens. 30: 166-172. PMID: 33394730
- WNK4 kinase: from structure to physiology. | Murillo-de-Ozores, AR., et al. 2021. Am J Physiol Renal Physiol. 320: F378-F403. PMID: 33491560
- Regulation of the WNK4-SPAK-NCC pathway by the calcium-sensing receptor. | Chávez-Canales, M., et al. 2023. Curr Opin Nephrol Hypertens. 32: 451-457. PMID: 37530086
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WNK4 Antibody (1E6) | sc-293369 | 100 µg/ml | $322.00 | |||
Nebulin Antibody (1F4) | sc-293370 | 100 µg/ml | $322.00 |