WNK2 Antibody (46.21): sc-100452

WNK2 Antibody (46.21) is a mouse monoclonal IgG1 kappa light chain antibody that detects WNK2 protein of human origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-WNK2 antibody (46.21) is available as a non-conjugated format. WNK2 is a member of the WNK (with no lysine (K)) kinase family, which plays a crucial role in regulating ion transport and blood pressure homeostasis. Located primarily in the kidney, heart, and muscle tissues, WNK2 is involved in signaling pathways that control sodium and potassium ion balance, making WNK2 essential for maintaining proper cellular function and overall cardiovascular health. Aberrant function of WNK2 and associated pathways has been linked to various conditions, including hypertension and renal disorders, highlighting WNK2′s importance in physiological and pathological processes. With high homology to other WNK kinases, WNK2 shares significant structural features that facilitate enzymatic activity, including a unique lysine residue that orients ATP for effective phosphorylation. This specificity in structure and function underscores WNK2′s relevance in both basic research and clinical applications, making anti-WNK2 antibody (46.21) an invaluable tool for scientists studying ion transport mechanisms and related diseases.

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WNK2 Antibody (46.21) References:

1. WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.  |  Xu, B., et al. 2000. J Biol Chem. 275: 16795-801. PMID: 10828064
2. Human hypertension caused by mutations in WNK kinases.  |  Wilson, FH., et al. 2001. Science. 293: 1107-12. PMID: 11498583
3. WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.  |  Veríssimo, F. and Jordan, P. 2001. Oncogene. 20: 5562-9. PMID: 11571656
4. Human hypertension caused by mutations in WNK kinases.  |  Hollenberg, NK. 2002. Curr Hypertens Rep. 4: 267. PMID: 12166403
5. Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.  |  Xu, BE., et al. 2002. J Biol Chem. 277: 48456-62. PMID: 12374799
6. Compilation and characterization of a novel WNK family of protein kinases in Arabiodpsis thaliana with reference to circadian rhythms.  |  Nakamichi, N., et al. 2002. Biosci Biotechnol Biochem. 66: 2429-36. PMID: 12506983
7. WNK kinases regulate thiazide-sensitive Na-Cl cotransport.  |  Yang, CL., et al. 2003. J Clin Invest. 111: 1039-45. PMID: 12671053
8. Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population.  |  Tobin, MD., et al. 2005. Circulation. 112: 3423-9. PMID: 16301342

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WNK2 Antibody (46.21) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-WNK2 Antibody (46.21) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WNK2 Antibody (46.21) Specifications

Alternate Product Name: WNK2

Product Clone Name: 46.21

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2118-2218

Epitope Target: WNK2

Epitope Species: human

Product Reactivity/Detection: WNK2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for WNK2 Antibody (46.21): N/A