Molecular structure of Wee1 Inhibitor II, CAS Number: 622855-50-9
Wee1 Inhibitor II (CAS 622855-50-9)
Alternate Names:
6-Butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione
Application:
Wee1 Inhibitor II is a potent, ATP-binding site-targeting inhibitor of Wee1
CAS Number:
622855-50-9
Purity:
≥97%
Molecular Weight:
418.9
Molecular Formula:
C24H19ClN2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
A pyrrolocarbazole compound that acts has been reported to be a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 59 nM) with a ~590-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 35 µM).
Wee1 Inhibitor II (CAS 622855-50-9) References
- 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. | Palmer, BD., et al. 2006. J Med Chem. 49: 4896-911. PMID: 16884302
- WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe. | De Witt Hamer, PC., et al. 2011. Clin Cancer Res. 17: 4200-7. PMID: 21562035
- Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. | Domínguez-Kelly, R., et al. 2011. J Cell Biol. 194: 567-79. PMID: 21859861
- WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis. | Garimella, SV., et al. 2012. Mol Cancer Res. 10: 75-85. PMID: 22112940
- Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition. | Cozzi, M., et al. 2012. Cell Cycle. 11: 1029-39. PMID: 22333592
- Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1. | Aarts, M., et al. 2012. Cancer Discov. 2: 524-39. PMID: 22628408
- Specific inhibition of Wee1 kinase and Rad51 recombinase: a strategy to enhance the sensitivity of leukemic T-cells to ionizing radiation-induced DNA double-strand breaks. | Havelek, R., et al. 2014. Biochem Biophys Res Commun. 453: 569-75. PMID: 25285634
- Chk1 and Wee1 control genotoxic-stress induced G2-M arrest in melanoma cells. | Vera, J., et al. 2015. Cell Signal. 27: 951-60. PMID: 25683911
- Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases. | Schmidt, M., et al. 2017. Molecules. 22: PMID: 29168755
- ATM, ATR, CHK1, CHK2 and WEE1 inhibitors in cancer and cancer stem cells. | Ronco, C., et al. 2017. Medchemcomm. 8: 295-319. PMID: 30108746
- Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na+ Channel 1.2 Macromolecular Complex. | Dvorak, NM., et al. 2021. Cells. 10: PMID: 34831326
Inhibitor of:
Enzyme, and Wee 1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Wee1 Inhibitor II, 1 mg | sc-311556 | 1 mg | $320.00 |