WDR42A Antibody (QS-5): sc-100898

WDR42A Antibody (QS-5) is a mouse monoclonal IgM antibody that detects WDR42A protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-WDR42A antibody (QS-5) is available as a non-conjugated format. WDR42A protein, also known as H326, is a 597 amino acid protein characterized by the presence of seven WD-repeats, which are structural motifs that typically form a tertiary propeller configuration. These WD-repeats are crucial for WDR42A protein′s function, as they facilitate interactions with various partner proteins, thereby playing a significant role in multiple cellular processes, including chromatin assembly, cell cycle regulation, signal transduction, RNA processing, apoptosis, and vesicular trafficking. The ability of WDR42A to participate in these essential signaling networks underscores its importance in maintaining cellular homeostasis and responding to environmental cues. Alternative splicing of the WDR42A gene results in the expression of two isoforms, further diversifying its functional roles within the cell.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

WDR42A Antibody (QS-5) References:

1. The WD repeat: a common architecture for diverse functions.  |  Smith, TF., et al. 1999. Trends Biochem Sci. 24: 181-5. PMID: 10322433
2. Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians.  |  Wolford, JK., et al. 2000. Gene. 241: 143-8. PMID: 10607908
3. Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation.  |  Underhill, DA., et al. 2000. Mamm Genome. 11: 633-8. PMID: 10920231
4. Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23.  |  Doudney, K., et al. 2001. Genomics. 72: 180-92. PMID: 11401431
5. WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.  |  Li, D. and Roberts, R. 2001. Cell Mol Life Sci. 58: 2085-97. PMID: 11814058
6. Structure and expression of Strabismus 1 gene on human chromosome 1q21-q23.  |  Katoh, M. 2002. Int J Oncol. 20: 1197-203. PMID: 12011999
7. Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2.  |  Mizutani, T., et al. 2005. Drug Metab Rev. 37: 235-52. PMID: 15747502
8. The WD-40 repeat.  |  van der Voorn, L. and Ploegh, HL. 1992. FEBS Lett. 307: 131-4. PMID: 1644165
9. Host cell targets of tegument protein VP22 of herpes simplex virus 1.  |  Li, M., et al. 2011. Arch Virol. 156: 1079-84. PMID: 21424732
10. Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A).  |  Wu, F., et al. 2012. FEBS Lett. 586: 1079-85. PMID: 22500989
11. The ancient regulatory-protein family of WD-repeat proteins.  |  Neer, EJ., et al. 1994. Nature. 371: 297-300. PMID: 8090199
12. Folding a WD repeat propeller. Role of highly conserved aspartic acid residues in the G protein beta subunit and Sec13.  |  Garcia-Higuera, I., et al. 1998. J Biol Chem. 273: 9041-9. PMID: 9535892