WBSCR22 Antibody (F-2): sc-376714

WBSCR22 Antibody (F-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects WBSCR22 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-WBSCR22 antibody (F-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. WBSCR22, also known as Williams-Beuren syndrome chromosomal region 22 protein, plays a crucial role as a nuclear methyltransferase, essential for regulating gene expression through DNA methylation. This function influences developmental processes and cellular differentiation, and dysregulation may contribute to Williams-Beuren syndrome (WBS) manifestations. WBS is a developmental disorder caused by a hemizygous microdeletion on chromosome 7q11.23, characterized by physical, cognitive, and behavioral traits, including facial dysmorphology, vascular stenoses, growth deficiencies, and neurological abnormalities. WBSCR22 gene, located within the WBS deletion, may significantly impact developmental symptoms associated with WBS due to encoded transcription factor loss. WBSCR22 consists of 281 amino acids and is predominantly expressed in kidney, heart, and skeletal muscle, with lower expression levels in lung, spleen, liver, and testis, highlighting potential importance in these tissues during development and function.

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WBSCR22 Antibody (F-2) References:

1. Bridging cognition, the brain and molecular genetics: evidence from Williams syndrome.  |  Bellugi, U., et al. 1999. Trends Neurosci. 22: 197-207. PMID: 10322491
2. Williams-Beuren syndrome: an update and review for the primary physician.  |  Lashkari, A., et al. 1999. Clin Pediatr (Phila). 38: 189-208. PMID: 10326175
3. A transcription factor involved in skeletal muscle gene expression is deleted in patients with Williams syndrome.  |  Tassabehji, M., et al. 1999. Eur J Hum Genet. 7: 737-47. PMID: 10573005
4. Characterization of 16 novel human genes showing high similarity to yeast sequences.  |  Stanchi, F., et al. 2001. Yeast. 18: 69-80. PMID: 11124703
5. Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome.  |  Doll, A. and Grzeschik, KH. 2001. Cytogenet Cell Genet. 95: 20-7. PMID: 11978965
6. Identification of additional transcripts in the Williams-Beuren syndrome critical region.  |  Merla, G., et al. 2002. Hum Genet. 110: 429-38. PMID: 12073013
7. Natural history of Williams syndrome: physical characteristics.  |  Morris, CA., et al. 1988. J Pediatr. 113: 318-26. PMID: 2456379

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WBSCR22 Antibody (F-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-WBSCR22 Antibody (F-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WBSCR22 Antibody (F-2) Specifications

Alternate Product Name: WBSCR22

Product Clone Name: F-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-281

Epitope Target: WBSCR22

Epitope Species: human

Product Reactivity/Detection: WBSCR22

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for WBSCR22 Antibody (F-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin