Molecular structure of W146, CAS Number: 909725-61-7
W146 (CAS 909725-61-7)
Alternate Names:
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid [(3R)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid W146 hydrate
CAS Number:
909725-61-7
Molecular Weight:
342.37
Molecular Formula:
C16H27N2O4P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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W146 (CAS 909725-61-7) References
- The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice. | Tarrasón, G., et al. 2011. Int Immunopharmacol. 11: 1773-9. PMID: 21798372
- 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. | Liu, J., et al. 2013. J Biochem Pharmacol Res. 1: 197-203. PMID: 25383272
- Regulation of endothelial nitric oxide synthase activation in endothelial cells by S1P1 and S1P3. | Tölle, M., et al. 2016. Biochem Biophys Res Commun. 476: 627-634. PMID: 27282481
- S1PR1 regulates NDV-induced IL-1β expression via NLRP3/caspase-1 inflammasome. | Gao, P., et al. 2022. Vet Res. 53: 58. PMID: 35854395
- Fingolimod does not prevent syndecan-4 shedding from the endothelial glycocalyx in a cultured human umbilical vein endothelial cell model of vascular injury. | Milford, EM., et al. 2022. Intensive Care Med Exp. 10: 34. PMID: 35980492
- Sphingosine-1-phosphate and ceramide-1-phosphate promote migration, pro-inflammatory and pro-fibrotic responses in retinal pigment epithelium cells. | Simón, MV., et al. 2022. Exp Eye Res. 224: 109222. PMID: 36041511
- Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP. | Wei, B., et al. 2022. Nat Commun. 13: 6909. PMID: 36376309
- Sphingosine-1-phosphate receptor modulation improves neurogenesis and functional recovery after stroke. | Huang, H., et al. 2022. FASEB J. 36: e22616. PMID: 36394527
- Sphingosylphosphorylcholine inhibits plasma cell differentiation and ameliorates experimental autoimmune encephalomyelitis. | Park, B., et al. 2023. Front Immunol. 14: 1151511. PMID: 37409121
- Sodium butyrate ameliorated diabetic nephropathy-associated tubulointerstitial inflammation by modulating the tight junctions of renal tubular epithelial cells. | Yang, T., et al. 2024. Food Funct. 15: 2628-2644. PMID: 38358014
Inhibitor of:
GDPD3, MFSD2B, SphK1, and SPHKAP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
W146, 1 mg | sc-507557 | 1 mg | $525.00 |