Molecular structure of VULM 1457, CAS Number: 228544-65-8
VULM 1457 (CAS 228544-65-8)
Alternate Names:
N-[2,6-bis(1-Methylethyl)phenyl]-N′-[4-[(4-nitrophenyl)thio]phenyl]urea
Application:
VULM 1457 is an inhibitor of SOAT (Acyl-CoA: cholesterol acyltransferase; ACAT)
CAS Number:
228544-65-8
Purity:
≥99%
Molecular Weight:
449.57
Molecular Formula:
C25H27N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. Decreases cholesterol levels in the liver and plasma of diabetic-hypercholesterolaemic rats.
VULM 1457 (CAS 228544-65-8) References
- The hypolipidemic effect of a new ACAT inhibitor, VULM 1457, in diabetic-hypercholesterolaemic rats. | Adameová, A., et al. 2005. Pharmazie. 60: 714-5. PMID: 16222877
- The ACAT inhibitor VULM1457 significantly reduced production and secretion of adrenomedullin (AM) and down-regulated AM receptors on human hepatoblastic cells. | Drímal, J., et al. 2005. Gen Physiol Biophys. 24: 397-409. PMID: 16474185
- Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats. | Adameová, A., et al. 2006. Pharmazie. 61: 807-8. PMID: 17020164
- The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA:cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in vivo. | Adameová, A., et al. 2007. Eur J Pharmacol. 576: 114-21. PMID: 17764671
- Effect of VULM 1457, an ACAT inhibitor, on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet. | Vojtassáková, E., et al. 2007. Gen Physiol Biophys. 26: 254-9. PMID: 18281742
Inhibitor of:
SOAT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VULM 1457, 10 mg | sc-204390 | 10 mg | $185.00 | |||
| US: Only available in the US | ||||||
VULM 1457, 50 mg | sc-204390A | 50 mg | $772.00 | |||
| US: Only available in the US | ||||||