Valproic Acid-d6 β-D-Glucuronide (CAS 60113-83-9 unlabeled)

Valproic Acid-d6 β-D-Glucuronide is a deuterium-labelled metabolite of Valproic Acid. Valproic Acid is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na⁺ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Metabolites of Valproic Acid are also available as:
Valproic Acid (sc-213144)
Valproic Acid, Sodium Salt (sc-202378)
3-Hydroxy Valproic Acid (sc-209599)
3-Keto Valproic Acid Sodium Salt (sc-216476)
4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) (sc-216870)
rac 5-Hydroxy Valproic Acid Sodium Salt (sc-208266)
Valproic Acid β-D-Glucuronide Allyl Ester (sc-220360)
Valproic Acid β-D-Glucuronide (sc-213145)

Labelled forms of Valproic Acid are available as:
Valproic Acid-d6 (sc-213146)
rac 5-Hydroxy Valproic Acid-d7 Sodium Salt (sc-219789)