Molecular structure of U-54494A hydrochloride, CAS Number: 112465-94-8
U-54494A hydrochloride (CAS 112465-94-8)
Application:
U-54494A hydrochloride is a benzamide NMDA antagonist
CAS Number:
112465-94-8
Molecular Weight:
391.8
Molecular Formula:
C18H24Cl2N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
U-54494A hydrochloride is a KOR (κ-opioid receptor) agonist. This compound also has potential uses as an NMDA antagonist.
U-54494A hydrochloride (CAS 112465-94-8) References
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- Possible mechanism involved in the anticonvulsant action of butorphanol in mice. | Manocha, A., et al. 2003. Pharmacol Biochem Behav. 74: 343-50. PMID: 12479953
- Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin. | Sethy, VH. and Sage, GP. 1992. Neuropharmacology. 31: 111-4. PMID: 1348110
- Studies on the anticonvulsant effect of U50488H on maximal electroshock seizure in mice. | Manocha, A., et al. 2003. Pharmacol Biochem Behav. 76: 111-7. PMID: 13679223
- The kappa opioid agonist U50,488 potentiates 6-hydroxydopamine-induced neurotoxicity on dopaminergic neurons. | Marin, C., et al. 2005. Exp Neurol. 191: 41-52. PMID: 15589511
- In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids, in the hippocampus. | Proietti, ML., et al. 1991. Neuropharmacology. 30: 637-42. PMID: 1656303
- The kappa opioid-related anticonvulsants U-50488H and U-54494A attenuate N-methyl-D-aspartate induced brain injury in the neonatal rat. | Hudson, CJ., et al. 1991. Brain Res. 564: 261-7. PMID: 1725768
- Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. | Mei, F., et al. 2016. J Neurosci. 36: 7925-35. PMID: 27466337
- A Cellular Assay for the Identification and Characterization of Connexin Gap Junction Modulators. | Danish, A., et al. 2021. Int J Mol Sci. 22: PMID: 33572565
- Dual inhibitory action of enadoline (CI977) on release of amino acids in the rat hippocampus. | Millan, MH., et al. 1995. Eur J Pharmacol. 279: 75-81. PMID: 7556386
- Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse. | Przewłocka, B., et al. 1994. Eur Neuropsychopharmacol. 4: 527-33. PMID: 7894264
- Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation? | Löscher, W. and Schmidt, D. 1994. Epilepsy Res. 17: 95-134. PMID: 8194514
- Metaphit-induced audiogenic seizures in mice: I. Pharmacologic characterization. | Debler, EA., et al. 1993. Epilepsia. 34: 201-10. PMID: 8384106
- Two metabolites of anticonvulsant U-54494A: their anticonvulsant activity and interaction with sodium channel. | Zhu, Y., et al. 1993. Brain Res. 606: 50-5. PMID: 8384924
- Developmental and regional alteration of kappa-opioid receptors in seizure-susceptible EL mouse brain. | Kai, T., et al. 1998. Neurochem Res. 23: 163-8. PMID: 9475510
Inhibitor of:
NMDA.Activator of:
KOR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U-54494A hydrochloride, 10 mg | sc-200479 | 10 mg | $135.00 | |||
U-54494A hydrochloride, 50 mg | sc-200479A | 50 mg | $595.00 |