Date published: 2025-10-19

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Tris(methylthio)methane (CAS 5418-86-0)

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Alternate Names:
Trimethyl trithioorthoformate
CAS Number:
5418-86-0
Purity:
≥98%
Molecular Weight:
154.32
Molecular Formula:
C4H10S3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tris(methylthio)methane is carboxylic anion equivalent. Tris(methylthio)methane finds utility as a versatile reagent in organic synthesis, playing roles as both a catalyst for polymer synthesis and a key component in the synthesis of various organosulfur compounds. Moreover, it contributes to the production of polysulfides. Notably, this compound has exhibited promising properties in inhibiting the growth of cancer cells and reducing tumor size.


Tris(methylthio)methane (CAS 5418-86-0) References

  1. Studies dealing with thionium ion promoted mannich cyclization reactions.  |  Padwa, A. and Waterson, AG. 2000. J Org Chem. 65: 235-44. PMID: 10813921
  2. Development of a Second Generation Coenzyme A Analogue Synthon.  |  Bibart, RT., et al. 1999. J Org Chem. 64: 2903-2909. PMID: 11674364
  3. From alkyl halides to alkyltrifluoromethyls using bromine trifluoride.  |  Hagooly, A., et al. 2002. J Org Chem. 67: 8430-4. PMID: 12444621
  4. Research on L-nucleosides. Synthesis and biological evaluation of a series of L- and D-2',3'-dideoxy-3'-[tris(methylthio)methyl]-beta-pentofuranosyl nucleosides.  |  Mugnaini, C., et al. 2003. Bioorg Med Chem. 11: 357-66. PMID: 12517431
  5. Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives.  |  Chand, P., et al. 2004. J Med Chem. 47: 1919-29. PMID: 15055992
  6. Determination of volatile organic compounds from truffles via SPME-GC-MS.  |  Mauriello, G., et al. 2004. J Chromatogr Sci. 42: 299-305. PMID: 15296529
  7. Attaching the fluorine atom to organic molecules using BrF3 and other reagents directly derived from F2.  |  Rozen, S. 2005. Acc Chem Res. 38: 803-12. PMID: 16231876
  8. Time-resolved infrared absorption study of cyclopentadienyl manganese tricarbonyl derivatives: Chelation of pendant sulfides in acetonitrile.  |  To, TT., et al. 2006. J Phys Chem A. 110: 10669-73. PMID: 16970355
  9. Solvent and structural effects on ultrafast chelation dynamics of arene chromium tricarbonyl sulfide derivatives.  |  To, TT., et al. 2007. J Phys Chem A. 111: 6933-7. PMID: 17628047
  10. Geographical traceability of Italian white truffle (Tuber magnatum Pico) by the analysis of volatile organic compounds.  |  Gioacchini, AM., et al. 2008. Rapid Commun Mass Spectrom. 22: 3147-53. PMID: 18798200
  11. Catalytic enantioselective synthesis of naturally occurring butenolides via hetero-allylic alkylation and ring closing metathesis.  |  Mao, B., et al. 2011. Org Lett. 13: 948-51. PMID: 21268603
  12. Methodological Advances Permit the Stereocontrolled Construction of Diverse Fully Synthetic Tetracyclines Containing an All-Carbon Quaternary Center at Position C5a.  |  Wright, PM. and Myers, AG. 2011. Tetrahedron. 67: 9853-9869. PMID: 22102762
  13. Identification of Odor-Active Compounds Released from a Damaged Plant of the Asian Skunk Cabbage Symplocarpus renifolius.  |  Sakamaki, K., et al. 2018. J Nat Prod. 81: 2710-2715. PMID: 30525605
  14. Tris(methylthio)methane produced by Mortierella hyalina affects sulfur homeostasis in Arabidopsis.  |  Tseng, YH., et al. 2022. Sci Rep. 12: 14202. PMID: 35987806
  15. Biosynthesis, behavior and fate of volatile organic sulfide in Lentinus edodes (Berk.) upon hot-air drying treatment.  |  Xi, J., et al. 2023. Food Chem. 412: 135528. PMID: 36716624

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tris(methylthio)methane, 25 g

sc-253792
25 g
$92.00