Molecular structure of Triparanol, CAS Number: 78-41-1
Triparanol (CAS 78-41-1)
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Application:
Triparanol is a Desmosterol Delta 24 (D24) reductase inhibitor
CAS Number:
78-41-1
Purity:
≥97%
Molecular Weight:
438.00
Molecular Formula:
C27H32ClNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Triparanol is a tertiary amine compound described to be a distal inhibitor of cholesterol biosynthesis through inhibition of DHCR24 (delta 24-reductase). It is a model compound for studying the regulation of cholesterol synthesis, the consequences of disrupted cholesterol homeostasis, and the cellular mechanisms that respond to changes in lipid composition. Triparanol has been utilized in studies exploring the relationship between cholesterol levels and other cellular processes, such as cell signaling, membrane fluidity, and the formation of lipid rafts. Triparanol has also been described as an inhibitor of Hedgehog pathway signaling, and has been used as a probe in studying the behaviors and mechanisms of this pathway.
Triparanol (CAS 78-41-1) References
- Calcium increase in mouse skeletal muscles by triparanol: a drug to induce myotonic dystrophy-like clinical manifestations. | Takahashi, MP., et al. 1999. Neurosci Lett. 272: 87-90. PMID: 10507548
- Absorption of morphine, butylscopolamine, mecamylamine and phenobarbitone from the small intestine of the triparanol-treated rat in situ. | Venho, VM. 1975. Arzneimittelforschung. 25: 232-4. PMID: 1173038
- Molecular mechanisms underlying limb anomalies associated with cholesterol deficiency during gestation: implications of Hedgehog signaling. | Gofflot, F., et al. 2003. Hum Mol Genet. 12: 1187-98. PMID: 12719383
- The cholesterol lowering effects of triparanol (MER-29) in subjects with and without coronary artery disease. | HOLLANDER, W., et al. 1960. Prog Cardiovasc Dis. 2: 637-44. PMID: 13852510
- The effects of triparanol (MER-29) in subjects with and without coronary artery disease. | HOLLANDER, W., et al. 1960. JAMA. 174: 5-12. PMID: 13852511
- Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. | Tiet, TD., et al. 2006. Am J Pathol. 168: 321-30. PMID: 16400033
- Inhibition of Sterol Biosynthesis in Chlorella sorokiniana by Triparanol. | Chan, JT. and Patterson, GW. 1974. Plant Physiol. 53: 244-9. PMID: 16658684
- Probucol and the cholesterol synthesis inhibitors simvastatin and triparanol regulate I ks channel function differently. | Hihara, T., et al. 2013. Hum Exp Toxicol. 32: 1028-37. PMID: 23424208
- Effects of triparanol and 20,25-diazacholesterol in CNS of rat: morphological and biochemical studies. | Suzuki, K., et al. 1974. Acta Neuropathol. 29: 141-56. PMID: 4374858
- Lipid composition and (Na+ + K+)-ATPase activity in rat lens during triparanol-induced cataract formation. | Mizuno, GR., et al. 1981. Biochim Biophys Acta. 644: 1-12. PMID: 6266459
- Fatty acid metabolism in Paramecium. Oleic acid metabolism and inhibition of polyunsaturated fatty acid synthesis by triparanol. | Rhoads, DE. and Kaneshiro, ES. 1984. Biochim Biophys Acta. 795: 20-9. PMID: 6466696
- Fungal transformations of triparanol. | Warner, SA., et al. 1982. Appl Environ Microbiol. 44: 1471-5. PMID: 7159089
- Correlation of pharmacological properties of a group of beta-blocker agents by molecular topology. | Garcia-March, FJ., et al. 1995. J Pharm Pharmacol. 47: 232-6. PMID: 7602487
- Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. | Bae, SH. and Paik, YK. 1997. Biochem J. 326 (Pt 2): 609-16. PMID: 9291139
Inhibitor of:
DHCR24, and DHCR7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Triparanol, 5 mg | sc-208472 | 5 mg | $240.00 | |||
Triparanol, 25 mg | sc-208472A | 25 mg | $795.00 |