Date published: 2026-5-29

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Triisopropylsilanol (CAS 17877-23-5)

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CAS Number:
17877-23-5
Molecular Weight:
174.36
Molecular Formula:
C9H22OSi
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Triisopropylsilanol (TIPS) is an organic compound that presents itself as a colorless liquid. It possesses the ability to dissolve in water, alcohol, and ether. As a silanol, it belongs to the category of alcohols that feature a silicon atom within their structure. Triisopropylsilanol finds application in a diverse range of fields, including serving as a surfactant, emulsifier, and lubricant. Moreover, it plays a role in the synthesis of organic compounds. Functioning as a surfactant, Triisopropylsilanol effectively reduces the surface tension of liquids. This attribute enables it to minimize the interfacial tension between immiscible liquids, such as oil and water. Furthermore, it acts as an emulsifier, effectively ensuring the harmonious mixing of two immiscible liquids.


Triisopropylsilanol (CAS 17877-23-5) References

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  2. Stability and cleavage conditions of (2-furyl)-L-alanine-containing peptides.  |  Schulz, A., et al. 2004. Protein Pept Lett. 11: 601-6. PMID: 15579131
  3. Solid-phase synthesis of cyclic hexapeptides wollamides A, B and desotamide B.  |  Tsutsumi, LS., et al. 2017. Tetrahedron Lett. 58: 2675-2680. PMID: 29129945
  4. Reduction of cysteine-S-protecting groups by triisopropylsilane.  |  Ste Marie, EJ. and Hondal, RJ. 2018. J Pept Sci. 24: e3130. PMID: 30353614
  5. Functionalized Resins for the Synthesis of Peptide Alcohols.  |  Ferrer-Gago, FJ., et al. 2020. Chemistry. 26: 379-383. PMID: 31609031
  6. 2,2'-Dipyridyl diselenide: A chemoselective tool for cysteine deprotection and disulfide bond formation.  |  Ste Marie, EJ. and Hondal, RJ. 2020. J Pept Sci. 26: e3236. PMID: 31856422
  7. Total synthesis of diazaquinomycins H and J using double Knorr cyclization in the presence of triisopropylsilane.  |  Prior, AM. and Sun, D. 2019. RSC Adv. 9: 1759-1771. PMID: 35516148
  8. S-Protected Cysteine Sulfoxide-Enabled Tryptophan-Selective Modification with Application to Peptide Lipidation.  |  Kobayashi, D., et al. 2022. ACS Med Chem Lett. 13: 1125-1130. PMID: 35859873
  9. Nickel-Catalyzed Homologation of Vinylidene Difluoride (CH2═CF2): Selective β-F vs β-H Elimination.  |  Sicard, AJ., et al. 2022. J Am Chem Soc. 144: 22713-22721. PMID: 36469940
  10. A new method for the synthesis of neoglycopeptides.  |  Hansen, PR., et al. 1998. Bioconjug Chem. 9: 126-31. PMID: 9460555

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Triisopropylsilanol, 1 g

sc-229584
1 g
$71.00