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Triethylenephosphoramide (CAS 545-55-1)

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Datasheets
Alternate Names:
TAPO; TEPA
Application:
Triethylenephosphoramide is a chemical used as insect chemosterilant
CAS Number:
545-55-1
Molecular Weight:
173.15
Molecular Formula:
C6H12N3OP
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Triethylenephosphoramide (TEPA) is a chemical used as insect chemosterilant, used in dyeing and is an antineoplastic. It has been studied for its ability to inhibit DNA synthesis and cell division. Triethylenephosphoramide is an alkylating agent, which means that it forms covalent bonds with DNA and other cellular components, causing DNA damage and inhibiting cancer cell growth. Triethylenephosphoramide is also a cholinesterase inhibitor, which means that it blocks the activity of cholinesterase enzymes in an insect′s nervous system. Cholinesterase enzymes are responsible for breaking down the neurotransmitter acetylcholine, which is involved in the transmission of nerve impulses. By blocking cholinesterase activity, Triethylenephosphoramide causes the accumulation of acetylcholine, which leads to overstimulation of the insect′s nervous system and ultimately paralysis and death.


Triethylenephosphoramide (CAS 545-55-1) References

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  2. Structure and carcinostatic activity of certain ethylenephosphoramides. II. Alkyl and aralkyl diethylenephosphoramides.  |  CROSSLEY, ML., et al. 1962. Cancer Res. 22: 549-55. PMID: 13882394
  3. Metabolic studies with certain ethyleneimine derivatives in relation to diuresis.  |  Jackson, H. and James, RM. 1965. Br J Pharmacol Chemother. 25: 223-7. PMID: 19108202
  4. Influence of the tissue distribution of ThioTEPA and its metabolite, TEPA, on the response of murine colon tumours.  |  Bibby, MC., et al. 1987. Cancer Chemother Pharmacol. 20: 203-6. PMID: 2445497
  5. Thirty compounds tested in the Drosophila wing spot test.  |  Graf, U., et al. 1989. Mutat Res. 222: 359-73. PMID: 2495439
  6. Gas chromatographic analysis of triethylenethiophosphoramide and triethylenephosphoramide in biological specimens.  |  McDermott, BJ., et al. 1985. J Chromatogr. 338: 335-45. PMID: 2581984
  7. Experimental correlations of in vitro drug sensitivity with in vivo responses to ThioTEPA in a panel of murine colon tumours.  |  Phillips, RM., et al. 1988. Cancer Chemother Pharmacol. 21: 168-72. PMID: 3127072
  8. Spatial and temporal variation of routine parameters: pitfalls in the cerebrospinal fluid analysis in central nervous system infections.  |  Djukic, M., et al. 2022. J Neuroinflammation. 19: 174. PMID: 35794632
  9. Fertilization and early embryonic development subsequent to mating with TEPA-treated male mice.  |  Joshi, SR., et al. 1970. Genetics. 65: 483-94. PMID: 4997168
  10. Cyclophosphamide therapy in prepubertal rats and subsequent reproductive performance.  |  Berry, CL. 1971. Arch Dis Child. 46: 709-11. PMID: 5118062
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  12. Correlations of alkylating activity and mutagenicity in bacteria of cytostatic drugs.  |  Hemminki, K., et al. 1983. Acta Pharmacol Toxicol (Copenh). 53: 421-8. PMID: 6659971
  13. Comparison of somatic and germ cell models for cytogenetic screening.  |  Holden, HE. 1982. J Appl Toxicol. 2: 196-200. PMID: 7185901
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Triethylenephosphoramide, 10 mg

sc-396213C
10 mg
$310.00

Triethylenephosphoramide, 25 mg

sc-396213
25 mg
$500.00

Triethylenephosphoramide, 25 mg

sc-396213-CW
25 mg
$715.00

Triethylenephosphoramide, 50 mg

sc-396213A
50 mg
$780.00

Triethylenephosphoramide, 100 mg

sc-396213B
100 mg
$1185.00

Triethylenephosphoramide, 250 mg

sc-396213D
250 mg
$2345.00