TRF2 Antibody (4A794): sc-52968
- TRF2 Antibody (4A794) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against full length TRF2 of human origin
- recommended for detection of TRF2 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TRF2 Antibody (4A794). This work is in progress.
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TRF2 Antibody (4A794) is a mouse monoclonal IgG1 antibody that detects TRF2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRF2, or telomeric repeat binding factor 2, plays a crucial role in maintaining telomere integrity by protecting chromosome ends from end-to-end fusions, which is vital for genomic stability and cellular longevity. TRF2 is primarily localized in the nucleolus during the G0 and S phases of the cell cycle, where TRF2 is essential for regulating telomere length and preventing chromosomal abnormalities. As cells enter the G2 phase, TRF2 diffuses out of the nucleolus, and during mitosis, TRF2 disperses from condensed chromosomes, returning to the nucleolus at cytokinesis. The dynamic localization of TRF2 ensures that telomere protection mechanisms are appropriately timed with the cell cycle, thereby preventing potential genomic instability that could lead to tumorigenesis. Anti-TRF2 antibody (4A794) serves as an invaluable tool for researchers studying telomere biology and its implications in cancer and aging.
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TRF2 Antibody (4A794) References:
- TRF2 and the evolution of the bilateria. | Duttke, SH., et al. 2014. Genes Dev. 28: 2071-6. PMID: 25274724
- The long and the short of TRF2 in neurogenesis. | Grammatikakis, I., et al. 2016. Cell Cycle. 15: 3026-3032. PMID: 27565210
- TRF2-independent chromosome end protection during pluripotency. | Ruis, P., et al. 2021. Nature. 589: 103-109. PMID: 33239783
- TRF2-mediated telomere protection is dispensable in pluripotent stem cells. | Markiewicz-Potoczny, M., et al. 2021. Nature. 589: 110-115. PMID: 33239785
- TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer. | Dinami, R., et al. 2022. Cancer Lett. 533: 215607. PMID: 35240232
- The shelterin component TRF2 mediates columnar stacking of human telomeric chromatin. | Wong, SY., et al. 2024. EMBO J. 43: 87-111. PMID: 38177309
- Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells. | Qiu, YD., et al. 2024. Acta Pharmacol Sin. 45: 1276-1286. PMID: 38438580
- Different Role of TRF1 and TRF2 Expression in Non-Small Cell Lung Cancers. | Chae, M., et al. 2024. Onco Targets Ther. 17: 463-469. PMID: 38855632
- TRF2-RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM-DNA2-dependent 5'-end resection. | Liang, F., et al. 2024. Nucleic Acids Res. 52: 9695-9709. PMID: 39082275
- Role of the telomeric factor TRF2 in post-hypoxic brain damages. | Gao, S., et al. 2024. Redox Biol. 75: 103278. PMID: 39128227
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRF2 Antibody (4A794) | sc-52968 | 100 µg/ml | $322.00 |